Denigma: Factor

che-3

Symbol: che-3
Name: abnormal CHEmotaxis
Entrez gene ID: 172593
Ensembl gene ID: F18C12.1
Species: Worm (Taxid: 6239)

Functional description:
Cytosolic dynein heavy chain, required for proper structure of sensory cilia.; Function as a motor for intraflagellar retrograde transport in chemosensory neurons. Functions in cilia biogenesis. [UniProt]

Observation:

Loss-of-function in che-3 extends lifespan by 50-100% depending on the allele, but life-extension is suppressed by daf-16 (in Bristol N2) [10617200]. che-3 mutations have defective sensory neurons [2428682; 10508861] and are defective in dye filling [2428682; 7705621] as well as dauer defective [1732156].

Interventions:

che-2 mutation +50 to +100%

Assays: Organismal Lifespan

Classification:

Gerontogene

Positive Gerontogene

References:

10508861: Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo.

Aging Relevance Analysis/Source:

GenAge