|
Symbol: SCP1 Name: S. cerevisiae CalPonin 1 Entrez gene ID: 854549 Ensembl gene ID: YOR367W Species: Yeast (Taxid: 4932) Functional description: Scp1p; Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin [Source:SGD;Acc:S000005894] [Ensembl] Observation: Increasing actin dynamics by deletion of SCP1, encoding an actin bundling protein, increases replicative lifespan by 67% as well as chronological lifespan by 88%, whereas its overexpression leads to elevuated ROS levels and reduces chronological lifespan (in KAY446 strain) [15024029]. SCP1 is related to mammalian SM22/transgelin which is induced during senescence [9570922]. Interventions: Assays: Replicative Lifespan Chronological Lifespan Mean: +67 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit