SAM1

Symbol: SAM1
Name: S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
Entrez gene ID: 850877
Species: Yeast (Taxid: 4932)

Functional description:
Sam1p; S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) [Source:SGD;Acc:S000004170] [Ensembl]

Observation:

Deletion of SAM1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043].



Interventions:
  • SAM1 deletion +15 to +20%

  • Assays: Replicative Lifespan
    Mean: +15 to +20

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MAT2A (9606)
  • MAT2A (9598)
  • MAT2A (9615)
  • MAT2A (9913)
  • Mat2a (10090)
  • Mat2a (10116)
  • M(2)21AB (7227)
  • AgaP_AGAP009447 (7165)
  • tag-32 (6239)
  • C06E7.3 (6239)
  • C06E7.1 (6239)
  • Y105C5B.12 (6239)
  • sams-1 (6239)
  • sam1 (4896)
  • SAM2 (4932)
  • SAM1 (4932)
  • KLLA0C01782g (28985)
  • AGOS_AFR692C (33169)
  • GeneID:2674392 (148305)
  • NCU02657 (5141)
  • MAT3 (3702)

  • Orthologs
  • sams-1 (6239)
  • sams-1 (6239)



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