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Symbol: alg-2 Name: Argonaute (plant)-Like Gene 2 Entrez gene ID: 173468 Ensembl gene ID: T07D3.7 Species: Worm (Taxid: 6239) Functional description: Protein ALG-2; Argonaute (plant)-Like Gene family member (alg-2) [Source:RefSeq peptide;Acc:NP_871992] [Ensembl]; alg-2 encodes a PAZ and PIWI-domain containing protein that is a member of the highly conserved eukaryotic RDE-1/AGO1/PIWI family of proteins that regulate posttranscriptional gene silencing (PTGS); ALG-2 functions with ALG-1 to control specific developmental timing events by positively regulating expression of small temporal RNAs (stRNAs) encoded by lin-4 and let-7; ALG-2 and ALG-1 are also required for RNAi in the germ line, although they are not required for RNAi in the soma; ALG-2 is expressed in nearly all cells from embryogenesis through adulthood and localizes to the cytoplasm. [WormBase] Observation: RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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