Denigma: Factor

Cdkn1a

Symbol: Cdkn1a
Name: Cyclin-dependent kinase inhibitor 1A
Alias: p21
Entrez gene ID: 12575
Ensembl gene ID: ENSMUSG00000023067
Species: Mouse (Taxid: 10090)

Functional description:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). [UniProt]

Observation:

Deletion of Cdkna1 (alias p21) prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres and improves the repopulation capacity and self-renewal of hematopoietic stem cells [17143283].

The p21(-/-) strains like the Cdkn1a(tmi/Tyj) exhibits enormous regenerative capacities as it closes ear holes similar to MRL mice [20231440; 21722344].

Interventions:

Cdkn1a knockout

Assays: Organismal Lifespan

Classification:

Aging Associated

Gerontogene

Positive Gerontogene

References:

17143283: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.

20231440: Lack of p21 expression links cell cycle control and appendage regeneration in mice.

21722344: The role of p21 in regulating mammalian regeneration.

Aging Relevance Analysis/Source:

GenAge