Denigma: Factor

PDE2

Symbol: PDE2
Name: High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
Entrez gene ID: 854542
Ensembl gene ID: YOR360C
Species: Yeast (Taxid: 4932)

Functional description:
phophodiesterase that catalyzes the hydrolysis of cAMP [2827010]; Pde2p; High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon [Source:SGD;Acc:S000005887] [Ensembl]

Observation:

Deletion of PDE2 decreases mean replicative lifespan by 26% [11000115] and also results in a shorter chronological lifespan [21076178]. PDE2 null mutant are sentive to oxidative stress [10394911].

PDE2 null mutant are sensitive to oxidative stress [10394911].

Interventions:

PDE2 Deletion -26%

Assays: Replicative Lifespan Chronological Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

2827010: SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae.

Aging Relevance Analysis/Source:

GenAge