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Symbol: vps-37 Name: related to yeast Vacuolar Protein Sorting factor Entrez gene ID: 178944 Ensembl gene ID: CD4.4 Species: Worm (Taxid: 6239) Functional description: Protein VPS-37; related to yeast Vacuolar Protein Sorting factor family member (vps-37) [Source:RefSeq peptide;Acc:NP_504474] [Ensembl]; vps-37 encodes the C. elegans ortholog of Saccharomyces cerevisiae Srn2p/Vps37p, a member of the endosomal sorting ESCRT-I complex that functions in endosomal sorting of mono-ubiquitinated membrane proteins; in C. elegans, VPS-37 is an essential component of the ESCRT-I complex (other members include VPS-28, MVB-12, and TSG-101) that affects the rate at which cell surface receptors are degraded and hence, the rate at which their activity is downregulated; a VPS-37::GFP fusion protein localizes to the cytosol and to endosomal membranes. [WormBase] Observation: RNA interference of vps-37 decreases median lifespan by 44% in wild-type animals, 47% in a daf-2 background and 33% in daf-2/daf-16 double mutants [18006689]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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