NPL3

Symbol: NPL3
Name: NA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
Entrez gene ID: 852042
Species: Yeast (Taxid: 4932)

Functional description:
Npl3p; RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm [Source:SGD;Acc:S000002840] [Ensembl]

Observation:

Replicative lifespan decreased by 50% in the alpha strain



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SRSF6 (9606)
  • SRSF6 (9913)
  • Srsf6 (10090)
  • Sfrs6 (10116)
  • SRSF6 (9031)
  • srsf6b (7955)
  • srsf6a (7955)
  • B52 (7227)
  • AgaP_AGAP004592 (7165)
  • rsp-1 (6239)
  • srp2 (4896)
  • NPL3 (4932)
  • KLLA0B00979g (28985)
  • AGOS_ADR183C (33169)
  • GeneID:5050615 (148305)
  • NCU07069 (5141)



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