NMT1

Symbol: NMT1
Name: N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
Entrez gene ID: 850892
Species: Yeast (Taxid: 4932)

Functional description:
Nmt1p; N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction [Source:SGD;Acc:S000004185] [Ensembl]

Observation:

nmt1-451D allele shortens mean and maximum replicative lifespan by 47 and 44% at 24 degree Celsius (permessive temperature). Mutants have decreased resistance to acute and gradual nutrient deprivation, even at the permissive temperature [10921902]. A NMT null mutant is lethal.



Interventions:
  • NMT1 mutation -47% -44%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 2406721: Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • NMT2 (9606)
  • NMT2 (9598)
  • NMT2 (9913)
  • Nmt2 (10090)
  • Nmt2 (10116)
  • NMT2 (9031)
  • nmt-1 (6239)
  • SPBC2G2.11 (4896)
  • NMT1 (4932)
  • KLLA0E19537g (28985)
  • AGOS_AAR077C (33169)
  • GeneID:2683117 (148305)
  • NCU06925 (5141)

  • Note: Is NMT1 null mutant meant instead of NMT?

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