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Symbol: Cct1 Name: CTP:phosphocholine cytidylyltransferase 1 Alias: Cct; cct1; CCT1; CG1049; CT41283; Dmel\CG1049 Entrez gene ID: 117353 Ensembl gene ID: FBgn0041342 Species: Fly (Taxid: 7227) Functional description: CTP:phosphocholine cytidylyltransferase 1; CTP:phosphocholine cytidylyltransferase 1 [Source:FlyBase gene name;Acc:FBgn0041342] [Ensembl]; The gene CTP:phosphocholine cytidylyltransferase 1 is referred to in FlyBase by the symbol Dmel\Cct1 (CG1049, FBgn0041342). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: choline-phosphate cytidylyltransferase activity. There is experimental evidence that it is involved in the biological process: eye development; endocytosis; determination of adult lifespan; oogenesis; imaginal disc-derived wing morphogenesis; establishment of ommatidial planar polarity. 39 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; multicellular structure; cytoplasmic part; external compound sense organ; ovariole; cell part; organ system subdivision; peripheral nervous system; endomembrane system; multi-tissue structure. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cytidyltransferase-related; Cytidylyltransferase; Rossmann-like alpha/beta/alpha sandwich fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, in stages of adults of both sexes. [FlyBase] Observation: Overexpression of Cct1 from a doxycycline-inducible promoter results in a 6 - 8% increase in mean lifespan (in the PdL x rtTA; Oregon-R x rtTA strain) [12620118]. Cct1 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages beyond the day of eclosion [23106705]. Interventions: Assays: Organismal Lifespan Mean: +6 to +8 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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