Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses

Study: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Species: Budding yeast
Assay: RLS
Data: genotype mean median max num pvalue
#temperature=30

wt 24.4 22 55 125 -
sod1 3.8 3 16 76 6.71E-32

wt 26.3 25 48 45 -
ctt1 24.9 24 47 43 6.64E-01

wt 28.3 29 46 55 -
cta1 29.0 27 54 45 7.68E-01

wt 26.2 26 42 600 -
msn2;msn4 29.3 30 57 623 1.76E-08

wt 26.5 26 56 545
hac1 29.1 29 57 543 6.77E-06

wt 24.2 23 51 150
rad52 10.8 33 10 130

# Note for some strain MLS had to be guessed.
Measurments:
  • wild-type_30_24_22_55_125
  • sod1_30_3_3_16_76
  • wild-type_30_26_25_48_45
  • ctt1_30_24_24_47_43
  • wild-type_30_28_29_46_55
  • cta1_30_29_27_54_45
  • wild-type_30_26_26_42_600
  • msn2;msn4_30_29_30_57_623
  • wild-type_30_26_26_56_545
  • hac1_30_29_29_57_543
  • wild-type_30_24_23_51_150
  • rad52_30_10_33_10_130
  • Comparisons:
  • sod1 vs. wild-type
  • ctt1 vs. wild-type
  • cta1 vs. wild-type
  • msn2;msn4 vs. wild-type
  • hac1 vs. wild-type
  • rad52 vs. wild-type

  • ID exp ctr Manipulation intervention mean median max pvalue T Gender epistasis
    103 sod1_30_3_3_16_76 wild-type_30_24_22_55_125 - SOD1 overexpression -84.4262295082 -86.3636363636 -70.9090909091 6.71e-32 30°C
    104 ctt1_30_24_24_47_43 wild-type_30_26_25_48_45 - CTT1 mutation -5.32319391635 -4.0 -2.08333333333 0.664 30°C
    105 cta1_30_29_27_54_45 wild-type_30_28_29_46_55 - CTA1 overexpression 2.47349823322 -6.89655172414 17.3913043478 0.768 30°C
    106 msn2;msn4_30_29_30_57_623 wild-type_30_26_26_42_600 - 11.8320610687 15.3846153846 35.7142857143 1.76e-08 30°C
    107 hac1_30_29_29_57_543 wild-type_30_26_26_56_545 - 9.81132075472 11.5384615385 1.78571428571 6.77e-06 30°C
    108 rad52_30_10_33_10_130 wild-type_30_24_23_51_150 - RAD52 deletion -55.3719008264 43.4782608696 -80.3921568627 30°C
    • 6 comparisons

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