Gerontology | 2 | 0 | | The ``Gerontology Ontology`` (the Ontology for Aging and Longevity, ``GERO``) is a mid-level ontology representing aging-related phenomena from the molecular and cellular levels to the social and demographic level. It aims to support gerontological ... |
Circadian Rhythm | 2 | 4 | Kapahi; Magalhaes; Wuttke; Katewa | Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
Tissue-Specific DR-Effects | 2 | 4 | Kapahi; Magalhaes; Wuttke; Li |
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
Aging Reprogramming | 0 | 3 | Stolzing; Wuttke; Johnson |
:Abstract: Ectopic expression of defined pluripotence-associated Factors reprograms adult somatic cells back to an Embryonic Stem Cell-like state. During this process the phenoytpic characteristics of Aging are also reverted. Cells can even be di... |
Curing Cancer | 1 | 3 | Coles; Debonneuil; Stambler | **Cancer** is ``function of Aging`` and its ``elimination is necessary`` for achieving longevity. Different **experimental approaches** can highly effectively **cure** or at least regress defined types of **Cancers**.
``Dr. Stephen Coles`` is an i... |
Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
Circadian Clock Controls Ageing | 2 | 3 | Magalhaes; Wuttke; Wood |
:Abstract: Dietary restriction without malnutrition delays ageing and extends lifespan, but the molecular mechanism is still unknown. Ageing gene expression changes originate from development and growth cessation, are modulated by diet, and manip... |
Pentose Phosphate Pathway | 2 | 3 | Magalhaes; Wuttke; Tang | The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
... |
Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
Circadian Rhythm | 2 | 4 | Kapahi; Magalhaes; Wuttke; Katewa | Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
Tissue-Specific DR-Effects | 2 | 4 | Kapahi; Magalhaes; Wuttke; Li |
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
Longevity Variant Database | 3 | 6 | Schaum; Wuttke; Adams; Betts-Lacroix; Juan; Fortney | ##########################
Longevity Variant Database
##########################
:Journal: Nucleic Acid Research
:Deadline: 25th August 2013
:Abstract: We are constructing the most comprehensive database on genetic variants associated with longe... |
miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
Microarray Game | 3 | 3 | Shytikov; Wuttke; Tang | There are many possibilities to analyze molecular Signatures. They can be compared to each other, meta-signature via Meta-Analysis can be derived, functional enriched terms can be assessed as well as Lifespan Factors identified.
It is possible to ... |
Continuous Longevity Meeting | 3 | 4 | Debonneuil; Wuttke; Singh; Maidano | The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
Curing Cancer | 1 | 3 | Coles; Debonneuil; Stambler | **Cancer** is ``function of Aging`` and its ``elimination is necessary`` for achieving longevity. Different **experimental approaches** can highly effectively **cure** or at least regress defined types of **Cancers**.
``Dr. Stephen Coles`` is an i... |
Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
Health Information | 1 | 2 | Debonneuil; Stambler | There is a need to ``collect data on people's health`` and try to **analyze it in relation to aging**, longevity and optimal life style.
There shall be a ``open database system`` that includes **clinical information** on patients most importantly ... |
Human Experimental Aging Biology | 2 | 3 | Debonneuil; Wuttke; Watson | The system of clinical trials in Western countries has been bogged down by high costs, red tape, and governmental restrictions to the point that within 10 years the engine of innovation in biotechnology will die [22378269].
In order to prevent thi... |
Grant Writing | 1 | 2 | Debonneuil; Stambler | Grant writing is the practice of ``completing an application process for funding`` provided by institution like government department, corporation, foundation or trust.
In the name of the International Longevity Alliance there shall be **assistanc... |
Educational Platform | 1 | 4 | Stambler; Kulaga; Katiyar; Xu | ``Eduction`` should be **free to anyone**. The International Longevity Alliance promotes eduction of people about longevity.
Classic Universities shall offer **Anti-Aging related courses**.
Further, something along the line of **Longevity Unive... |
Grant Writing | 1 | 2 | Debonneuil; Stambler | Grant writing is the practice of ``completing an application process for funding`` provided by institution like government department, corporation, foundation or trust.
In the name of the International Longevity Alliance there shall be **assistanc... |
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