Authors: Yang, Jingye; Dungrawala, Huzefa; Hua, Hui; Manukyan, Arkadi; Abraham, Lesley; Lane, Wesley; Mead, Holly; Wright, Jill; Schneider, Brandt L
Abstract: Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a genetic link between cell size, growth rate and lifespan. Mutations that increase cell size concomitantly increase growth rate and decrease lifespan. As a result, large cells grow, divide and age dramatically faster than small cells. Conversely, small cell mutants age slowly and are long-lived. Investigation of the mechanisms involved suggests that attainment of a maximal size modulates lifespan. Indeed, cumulative results revealed that life expectancy is size-dependent, and that the rate at which cells age is determined in large part by the amount of cell growth per generation.
Keywords: Cell Aging/*physiology; Cell Division/*physiology; *Cell Enlargement; Cell Proliferation; *Cell Size; Mutation/physiology; Yeasts/*cytology/*physiology|
Journal: Cell Cycle Volume: 10 Issue: 1 Pages: 144-55 Date: Jan. 21, 2011 PMID: 21248481 |
Yang, Jingye, Dungrawala, Huzefa, Hua, Hui, Manukyan, Arkadi, Abraham, Lesley, Lane, Wesley, Mead, Holly, Wright, Jill, Schneider, Brandt L (2011) Cell size and growth rate are major determinants of replicative lifespan. Cell Cycle 10: 144-55.
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