New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.

Authors: Nakaya S; Mizuno S; Ishigami H; Yamakawa Y; Kawagishi H; Ushimaru T

Abstract: The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.

Journal: Bioscience, biotechnology, and biochemistry Volume: 76 Issue: 6 Pages: 1226-8 Date: July 14, 2012 PMID: 22790951

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Citation:

Nakaya S, Mizuno S, Ishigami H, Yamakawa Y, Kawagishi H, Ushimaru T (2012) New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound. Bioscience, biotechnology, and biochemistry 76: 1226-8.

Study Lifespan Factors:

Rapa Rapamycin

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