Molecular mechanisms of yeast aging.

Authors: Sinclair DA; Mills K; Guarente L

Abstract: The life cycle of many organisms involves a progressive decline in fitness and fecundity with age, and yeast is no exception. Many theories have been proposed to explain the mortality of yeast cells, including the increase in cell size and accumulation of bud scars on the cell surface. None of these has survived closed scrutiny. However, recent discoveries might have validated one aging model in which the triggering of a molecular aging clock results in the replication and accumulation of a senescence factor that eventually overwhelms old cells.

Keywords: DNA, Fungal/metabolism; DNA, Ribosomal/metabolism; Genes, Fungal; Models, Biological; Saccharomyces cerevisiae/*cytology/genetics/growth & development
Journal: Trends in biochemical sciences
Volume: 23
Issue: 4
Pages: 131-4
Date: May 19, 1998
PMID: 9584615
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Citation:

Sinclair DA, Mills K, Guarente L (1998) Molecular mechanisms of yeast aging. Trends in biochemical sciences 23: 131-4.



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