Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.

Authors: Feng J; Zhang J; Liu M; Wan G; Qi K; Zheng C; Lv Z; Hu C; Zeng Y; Gregory SG; Yang Z

Abstract: Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p=0.003, OR: 2.01, 95%CI: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p<0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F.

Keywords: Aged; Aged, 80 and over; Aging/*genetics/physiology; Asian Continental Ancestry Group/*genetics; China/epidemiology; DNA, Mitochondrial/*genetics; Female; Gene Frequency; Genotype; Haplotypes/*genetics; Humans; Longevity/*genetics/physiology; Middle Aged; Phenotype; Phylogeny
Journal: Experimental gerontology
Volume: 46
Issue: 12
Pages: 987-93
Date: Sept. 29, 2011
PMID: 21945877
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Citation:

Feng J, Zhang J, Liu M, Wan G, Qi K, Zheng C, Lv Z, Hu C, Zeng Y, Gregory SG, Yang Z (2011) Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China. Experimental gerontology 46: 987-93.


Longevity Variant Associations (p-value):
  • mtDNA haplogroups (0.003)

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