Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum

Biosci Biotechnol Biochem. 2011;75(4):800-3. doi: 10.1271/bbb.100918. Epub 2011 Apr 22.

Abstract

Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / drug effects*
  • Ergosterol / chemistry
  • Ergosterol / isolation & purification*
  • Ergosterol / pharmacology*
  • Reishi / chemistry*
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / physiology
  • Spores, Fungal / chemistry*

Substances

  • Ergosterol