Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene.

Authors: Weng, Yufang; Xiang, Lan; Matsuura, Akira; Zhang, Yang; Huang, Qianming; Qi, Jianhua

Abstract: Two novel ergosterol derivatives, ganodermasides A and B, hydroxylated at C-15 were isolated from the methanol extract of spores of a medicinal mushroom, Ganoderma lucidum, showed to extend the replicative life span of Saccharomyces cerevisiae, a yeast of K6001 strain. The stereostructures of ganodermasides A and B were determined based on the spectroscopic analysis and comparison of spectroscopic data. These new sterols have a 4, 6, 8(14), 22-tetraene-3-one unit with a unique hydroxylation at C-15. The anti-aging activity of these compounds on yeast is comparable to a well-known substance, resveratrol. Based on results of the investigation of the mechanism of biological activity, ganodermasides A and B regulated UTH1 expression in order to extend the replicative life span of yeast.

Keywords: Aging/drug effects; Drugs, Chinese Herbal/chemistry/isolation & purification/pharmacology; Ergosterol/chemistry/*isolation & purification/*pharmacology; Gene Expression Regulation, Fungal/drug effects; Heat-Shock Proteins/*genetics/metabolism; Membrane Proteins/*genetics/metabolism; Mitochondrial Proteins/*genetics/metabolism; Molecular Structure; Reishi/*chemistry; Saccharomyces cerevisiae/*drug effects; Saccharomyces cerevisiae Proteins/*genetics/metabolism; Spores, Fungal/*chemistry
Journal: Bioorg Med Chem
Volume: 18
Issue: 3
Pages: 999-1002
Date: Jan. 23, 2010
PMID: 20093034
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Citation:

Weng, Yufang, Xiang, Lan, Matsuura, Akira, Zhang, Yang, Huang, Qianming, Qi, Jianhua (2010) Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. Bioorg Med Chem 18: 999-1002.


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