SASPense and DDRama in cancer and ageing.

Authors: Fumagalli M; d'Adda di Fagagna F

Abstract: Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.

Keywords: Cell Aging/*physiology; Cell Cycle Proteins/genetics/metabolism; Cells, Cultured; Cytokines/*secretion; *DNA Damage; DNA-Binding Proteins/genetics/metabolism; Fibroblasts/cytology/metabolism/radiation effects; Humans; Interleukin-6/secretion; Male; Models, Biological; Nuclear Proteins/genetics/metabolism; Protein-Serine-Threonine Kinases/genetics/metabolism; RNA, Small Interfering/genetics; Signal Transduction/*physiology; Transfection; Tumor Suppressor Proteins/genetics/metabolism

Journal: Nature cell biology Volume: 11 Issue: 8 Pages: 921-3 Date: Aug. 4, 2009 PMID: 19648977

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Citation:

Fumagalli M, d'Adda di Fagagna F (2009) SASPense and DDRama in cancer and ageing. Nature cell biology 11: 921-3.

Lifespan Factors:

CCL2 chemokine (C-C motif) ligand 2

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