Authors: Smith DL Jr; Robertson HT; Desmond RA; Nagy TR; Allison DB
Abstract: OBJECTIVE: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor. RESULTS AND CONCLUSION: Using data from a 2-year toxicology study of sibutramine in Sprague-Dawley CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared with controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate.
Keywords: Animals; Appetite Depressants/*pharmacology; Cyclobutanes/*pharmacology; Dose-Response Relationship, Drug; Eating/*drug effects; Longevity/*drug effects/physiology; Mice; Obesity/drug therapy; Rats; Rats, Sprague-Dawley; Serotonin Uptake Inhibitors/*pharmacology; Weight Loss/*drug effects/physiology|
Journal: International journal of obesity (2005) Volume: 35 Issue: 5 Pages: 652-7 Date: Nov. 17, 2010 PMID: 21079617 |
Smith DL Jr, Robertson HT, Desmond RA, Nagy TR, Allison DB (2011) No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight. International journal of obesity (2005) 35: 652-7.
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