Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
9 LDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
16 N-acetyl glycoprotein decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
21 Acetoacetate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
22 D-3-hydroxybutyrate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
24 Citrate decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
26 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
29 Choline decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
30 Glycerophosphocholine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
33 Trimethylamine-N-Oxide increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
36 alpha- and beta-glucose decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
37 Glycine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
39 AMP/ATP increases 6239 Apfeld et al., 2004 15574588 whole body Age 4 day 18 day Hemaphrodite AMP/ATP ratio in living animals increases from <0.1 at day 4 of adulthood to 0.8 at day 18 (an age near the maximum lifespan of the population). Linear regression indicates a strong correlation between AMP/ATP ratio and life expectancy.
43 Follicle stimulating hormone increases 9606 Jeff — — Age 40 year — male and emale Follicle stimulating hormone increases dramatically and becomes much more bioactive after the age of 40 in both men and women.
44 Luteneinzing hormone increases 9606 Jeff — — Age 40 year — male and female Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women.
45 human chorionic gonadotrophin increases 9606 Jeff — — Age 40 year — male and female human chorionic gonadotrophin hCG increases in both men and women after age 40.
64 Decrease in WNT gene expression 9606 RoSyBa 2011 — adipose-derived stem cells age 40 year 60 year females A dramtic decrease in WNT gene expression occurs in Adipose-dreived stem cells from females at the age of 40-60 years [RoSyBa 2011].
67 Bone loss 10090 — 13678781 bone age 42 week 104 week male In young mice the rapid growth is marked by substantial increase in bone size, mineral mass and mechanical properties. Maturation occurring between 12 and 42 weeks of age was characterized with the maintenance of bone mass and mechanical properties. From the peak levels, mice aged for 104 weeks exhibited decreased whole femur mass, percentage of mineralization diminished whole bone stiffness, energy to fracture and decreased cortical thickness. Periosteal perimeter and, consequently the cross-sectional moments of inertia continued to increase through 104 weeks, compensating for cortical thinning and increased brittleness due to decreased mineralization and stiffness. The shape of the mid-diaphysis became increasingly less elliptical in aged mice. After 52 weeks excessive endocortical resorption appeared, indicating a shift in normal mechanisms regulating bone shape and locating, suggestive of remodelling [13678781].
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
54 DHEA decreases 9544 Lane et al., 1997 9215277 serum Age 5 year 26 year males/females Males and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. The proportional age-related loss of DHEAS in rhesus moneys is over twice the rate of decline observed in humans [9215277].
86 Clonal mosicaism frequency increases 9505 Hunter et al. 2012 — blood — 50 79 female/male Detectable clonal mosaicism frequency in peripheral blood is low (<0.5 %) from birth until 50 years of age, after which it rapidley rises to 2-3% in the elderly. The frequency of mosic abnormalities increases with age, from 0.23% under 50 years to 1.91% between 75 and 79 years [Hunter et al. 2012].
58 Hippocampal atrophy 9606 — — Hippocampus age 56 84 males/females Shrinkage of hippocampus occurs with age. Several genes and genomic loci are associated with this process, among them are genes implicated in cell death (HRK), embryonic development (WIF1), diabetes (DPP) and neuronal migration (ASTN2) [22504421;22504417].
46 DHEA declines 9606 Jeff — — — 70 — male —
47 Melatonin declines 9606 — — — Age 70/35 year — male/female Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)).
48 Growth hormone declines 9606 — — — Age 70/35 year — male/female —
49 Progesterone declines 9606 — — — Age 70/35 year — male/female —

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