Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
72 IGF2 level changes 9606 — 3322823 plasma age — — — Circulating IGF2 reaches “adult” levels early in childhood, and changes are relatively small as a function of increasing age [3322823].
54 DHEA decreases 9544 Lane et al., 1997 9215277 serum Age 5 year 26 year males/females Males and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. The proportional age-related loss of DHEAS in rhesus moneys is over twice the rate of decline observed in humans [9215277].
55 DHEA deline slows 9544 Lane et al., 199 9215277 serum diet DR — males/females DR slows postmaturational decline in serum DHEAS levels form the age of 6.5 to 9.5 [9215277].
52 DHEA decreases 9606 Hinson and Raven, 1999 10495400 serum age 25 year 85 year males/females DHEAS (Dehydroepiandrosterone sulphate) is the most abundant circulating steroid secreted by adrenal glands. Duo to its position int the steroid cascade DHEA act like kind of ”the mother steroid” (Regelson et al., 1994). DHEA reaches its highest levels at age 20-24. Its serum concentration declines with increasing age after 25 years and diminishes about 95% by 85 years. DHEA deficiency syndrome is a new term for old age [10495400].
53 DHEA increases 9606 Hinson and Raven, 1999 10495400 serum age 10 year 20 year males/females DHEA reaches its highest levels at age 20-24 [10495400].
1 ROS production increases 4932 Laun et al., 2001 11251834 — Age young old — —
85 Cell proliferation decreases 10116 — 11744049 — Diet — — — 24 month DR in rats inhibits cell proliferation in glandular stomach and liver tissue [11744049].
41 Mitochondrial dysfunction increases 9606 Petersen et al., 2003 12750520 muscle Age — — — Aging is accompanied by an increase in mitochondrial dysfunction in muscle of humans [12750520].
67 Bone loss 10090 — 13678781 bone age 42 week 104 week male In young mice the rapid growth is marked by substantial increase in bone size, mineral mass and mechanical properties. Maturation occurring between 12 and 42 weeks of age was characterized with the maintenance of bone mass and mechanical properties. From the peak levels, mice aged for 104 weeks exhibited decreased whole femur mass, percentage of mineralization diminished whole bone stiffness, energy to fracture and decreased cortical thickness. Periosteal perimeter and, consequently the cross-sectional moments of inertia continued to increase through 104 weeks, compensating for cortical thinning and increased brittleness due to decreased mineralization and stiffness. The shape of the mid-diaphysis became increasingly less elliptical in aged mice. After 52 weeks excessive endocortical resorption appeared, indicating a shift in normal mechanisms regulating bone shape and locating, suggestive of remodelling [13678781].
38 HDL increases 9606 Fontana et al., 2004 15096581 Plasma Diet Chronic DR — — —
39 AMP/ATP increases 6239 Apfeld et al., 2004 15574588 whole body Age 4 day 18 day Hemaphrodite AMP/ATP ratio in living animals increases from <0.1 at day 4 of adulthood to 0.8 at day 18 (an age near the maximum lifespan of the population). Linear regression indicates a strong correlation between AMP/ATP ratio and life expectancy.
40 Accumulation of lipofuscin-like fluorescent pigment 6239 Apfeld et al., 2004 15574588 intestine Age 1 day 7 day Hemaphrodite A lipofuscin-like fluorescent pigment accumulates in an age-dependent manner in the intestine (Garigan et al., 2002; Herndon et al., 2002). It accumulates at a faster rate in aak-2 mutant, which have a shortened lifespan [15574588].
81 elt-5 expression increases 6239 17608836 17608836 — age — — — Expression of elt-5 increases with during devleopment and aging [17608836].
82 elt-6 expression increases 6239 — 17608836 — age — — — Expression of elt-6 increases during devleopment and aging [17608836].
83 elt-3 expression increases 6239 — 17608836 — age — — — Expression of elt-3 increases during devleopment and aging [17608836].
51 DHEA increases 9606 Willcox et al., 2007 17986602 serum diet Okinawa — — Okinawa aged 65-plus have relatively high DHEA levels.
124 Reduced expression of autophagy genes 7227 — 18059160 neural age old young — The expression of several autophagy genes is reduced in neural tissues as a normal part of aging [18059160].
125 Insoluble ubiquitinated proteins accumulate 7227 — 18059160 neuronal age old young — Insoluble ubiquitinated proteins, markers of neuronal aging and degeneration, accumulate with aging in concomitantly with the age-dependent suppression of autopagy [18059160].
130 Melatonin decreases — — 18212404 — age old young — Melatonin level decrease with age [reviewed in 18212404].
79 Vacuolar membrane deteriorates 4932 — 18690010 — age — — — The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
101 Enhanced mitochondrial function 7227 Zid et al. 2009 19804760 — diet DR AL — Flies upon DR have enhanced mitochondrial function, which is mediated by enhanced mRNA translation of nuclear-encoded mitochondrial mRNAs in a d4E-BP dependent manner [19804760]
62 Fertility declines 6239 — 20041217 whole body age — — females Fertility and reproduction sharply decline in early/mide-adulthood, folloed by a long post-reproductuve period, followed by a long-post-reproductive period [6,7 in 20041217].
2 Downregulation of exo-3 6239 Schlotterer et al., 2010 20346071 Whole body Age — — — —
103 Decreased stem cell activity — — 20504968 — age — — — Advanced age is associated with decreased stem cell activity [20504968].

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