Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
16 N-acetyl glycoprotein decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
17 N-acetyl glycoprotein increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
18 N-acetyl glycoprotein increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
19 Methionine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
20 Methionine increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
21 Acetoacetate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
22 D-3-hydroxybutyrate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
23 D-3-hydroxybutyrate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
24 Citrate decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
25 Citrate increases 10099 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
26 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
27 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
28 Trimethylamine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
29 Choline decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
30 Glycerophosphocholine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
31 Glycerophosphocholine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
32 Glycerophosphocholine increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks — male —
33 Trimethylamine-N-Oxide increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
34 Scyllo-inositol increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks — male —
36 alpha- and beta-glucose decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
37 Glycine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks — male —
60 Protein aggregation 6239 — 22103665 whole body age 1 day 11 day hermaphrodites protein aggreation accumulate in aged animals. Hundrets of protein are enriched in an SDS-insoluble fraction in aged nematode adn alre largely absent from similiar protein fraction in young nematodes. Genes encoding proteins that become insoluble with age are enriched for modifiers of lifespan [22103665].
61 Loss of protein homeostasis 6239 — 22103665 whole body — 1 day 11 day hermaphrodites Loss in protein homeostasis during aging may lead to impaird protein solubility and cellular dysfunction [22103665].
126 Elevated long-chain lactosylceramides 9606 — 21687659 fibroblasts age old young — Long-chain lactosylceramides (LacCers) are significantly elevated in human fibroblasts isolated from elderly individuals [21687659].
127 Accumulation of long-chain glycosphingolipids 10090 — 21687659 kidney age 17 month 3 month — Measurement of sphingolipid profiles in young (3 months), middle aged (9 moths) and old (17 months) C57BL/6 mice in kidney reveals a dramatic elevations in long-chain hexosylceramides (HexCer) and lactosylceramides, with C14- and C16-lactosylcermaides (LacCers) elevated as much as 8 and 12-fold, respectively. Similar changes occur in liver and brain. DR prevents the decline in kidney function, inhibits the accumulation of long-chain HexCer/LacCers and and also prevents the age-associated elevation of enzymes involved in their synthesis [21687659].

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