Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
53 DHEA increases 9606 Hinson and Raven, 1999 10495400 serum age 10 year 20 year males/females DHEA reaches its highest levels at age 20-24 [10495400].
54 DHEA decreases 9544 Lane et al., 1997 9215277 serum Age 5 year 26 year males/females Males and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. The proportional age-related loss of DHEAS in rhesus moneys is over twice the rate of decline observed in humans [9215277].
55 DHEA deline slows 9544 Lane et al., 199 9215277 serum diet DR — males/females DR slows postmaturational decline in serum DHEAS levels form the age of 6.5 to 9.5 [9215277].
56 Ability to make decisions in novel sitations decreases 9606 Samanez-Larkin et al., 2012 22496578 — age 21 year 85 year males/females The ability to make decisions in novel sitations decreases with age from 21 to 85 years [22496578].
57 White matter integrity decreases 9606 Samanez-Larkin et al., 2012 22496578 white matter age 21 year 85 year males/females Older age is associated with decreased reward learning and decreased white matter integrity in specific pathways running form the thalamus to the medial prefrontal cortex and from the meial prefrontal cortex to the ventral stratium
58 Hippocampal atrophy 9606 — — Hippocampus age 56 84 males/females Shrinkage of hippocampus occurs with age. Several genes and genomic loci are associated with this process, among them are genes implicated in cell death (HRK), embryonic development (WIF1), diabetes (DPP) and neuronal migration (ASTN2) [22504421;22504417].
59 Deteriorarition of circadian rhytms 10090 Farajnia, et al 2012 — Suprachiasmatic Nucleus age 2 month 30 month — Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuron’s rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm.
60 Protein aggregation 6239 — 22103665 whole body age 1 day 11 day hermaphrodites protein aggreation accumulate in aged animals. Hundrets of protein are enriched in an SDS-insoluble fraction in aged nematode adn alre largely absent from similiar protein fraction in young nematodes. Genes encoding proteins that become insoluble with age are enriched for modifiers of lifespan [22103665].
61 Loss of protein homeostasis 6239 — 22103665 whole body — 1 day 11 day hermaphrodites Loss in protein homeostasis during aging may lead to impaird protein solubility and cellular dysfunction [22103665].
62 Fertility declines 6239 — 20041217 whole body age — — females Fertility and reproduction sharply decline in early/mide-adulthood, folloed by a long post-reproductuve period, followed by a long-post-reproductive period [6,7 in 20041217].
63 Fertility declines 9606 20041217 — whole body age — — females Female fertility declines in the mid-adulthood and reproduction ceases, followed by a long post-reproductive period [Refs in 20041217].
64 Decrease in WNT gene expression 9606 RoSyBa 2011 — adipose-derived stem cells age 40 year 60 year females A dramtic decrease in WNT gene expression occurs in Adipose-dreived stem cells from females at the age of 40-60 years [RoSyBa 2011].
65 Protein expression variation increases 4932 Levy et al., 2012 — — age — — — Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
66 Tsl1 abundance increases 4932 Levy et al., 2012 — — age — — — Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
67 Bone loss 10090 — 13678781 bone age 42 week 104 week male In young mice the rapid growth is marked by substantial increase in bone size, mineral mass and mechanical properties. Maturation occurring between 12 and 42 weeks of age was characterized with the maintenance of bone mass and mechanical properties. From the peak levels, mice aged for 104 weeks exhibited decreased whole femur mass, percentage of mineralization diminished whole bone stiffness, energy to fracture and decreased cortical thickness. Periosteal perimeter and, consequently the cross-sectional moments of inertia continued to increase through 104 weeks, compensating for cortical thinning and increased brittleness due to decreased mineralization and stiffness. The shape of the mid-diaphysis became increasingly less elliptical in aged mice. After 52 weeks excessive endocortical resorption appeared, indicating a shift in normal mechanisms regulating bone shape and locating, suggestive of remodelling [13678781].
68 Increase in upper and central body fat deposition 9606 — 2921472 — age — — — There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472].
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
70 IGF1 levels decline 9606 — 3322823 plasma age — — — A decline in IGF1 expression occurs with age progression. Levels of circulating IGF1 in humans are low at birth, rise progressively during childhood and peak during midadolescence, and then progressively fall as a function of age. Reduction in levels of circulating IGR1 is related to decreased secretion of growth hormone [3322823].
71 Telomere shortening 10090 — 22585399 — age — — — Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880].
72 IGF2 level changes 9606 — 3322823 plasma age — — — Circulating IGF2 reaches “adult” levels early in childhood, and changes are relatively small as a function of increasing age [3322823].
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
74 Reduced regenerative capacity — — — — — — — — Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
75 Metabolic and mitochondrial decline 10090 — 22585399 — age — — males/females 2 years old mice exhibit metabolic and mitochondrial decline [22585399].
76 OSH5 upregulation 4932 Gebre et al. unpublished — — age — — — OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
77 Osh6 downregulation — Gebre et al., unpublished — — age — — — Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].

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