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Symbol:	In the case of genes providing the correct gene symbol and species name would be normally sufficient to identify a gene. Other fields such as gene name and identifiers will be automatically populated.
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Entrez gene ID:
Ensembl gene ID:
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Taxid:	This field will be autofilled if you provide a species name
Species:	--------- Budding yeast Nematode Fruit fly House mouse Norway rat Zebrafish Podospora anserine Fission yeast Capuchin Syrian hamster Bony fish Rhesus monkey Marmoset Human Cattle Bowhead whale
Observation:	Please provide references to the evidence why this factor was chosen to be classified. In the ideal case provide a PMID in square brackets at the end of the sentence. Multiple PMIDs can be separated by semicolon, e.g. "The gene XYZ was associated with aging in some way [12345; 67890].
Comment:
Assay:	RLS CLS Organismal
Classifications:	Age-Related Disease Associated Oxidative Stress Aging Associated Aging Differential Aging Induced Aging Methylated Aging-Suppressed Aging-Suppressor Negative Aging-Suppressor Positive Aging-Suppressor Gero-Enhancer Gero-Suppressant Gerontogene Negative Gerontogene Positive Gerontogene Longevity-Associated Longevity-Differential Longevity-Induced Longevity-Suppressed Senescence-Associated Senescence-Differential Senescence-Induced Senescence-Suppressed Cancer-Related Oncogene Tumor-Suppressor Clock-Related Circadian Differential Clock Modulator High Amplitude Long Period Short Period Clock Output Clock Systemic Core Clock Pacemaker DR-Associated DR-Differential DR-Induced DR-Suppressed DR-Essential DR-Essential Ortholog DR-Essential Paralog DR-Mimetic Embryonic Lethal Imprinted Maternal Imprinted Paternal Imprinted Juvenile-Associated Juvenile-Differential Juvenile-Induced Juvenile-Suppressed No Age Effect Stem Cell Related Transcription Factor
Intervention:	elo-1 RNAi elo-2 RNAi fat-4 RNAi fat-3 RNAi Diazaborine Dinitrophenol Deletion of mitochondrial DNA Spermidine Mitochondrial back-signaling Transplantation of young thymus aak-2 mutation aak-2 overexpression High-temperature pulse (HTP) Hormesis age-2 mutation apr-1 RNAi Hesperidin treatment DHEA treatment CTT1 mutation CTT1 deletion CTT1 overexpression SCH9 Deletion TOR1 Deletion RAS2 deletion Buffering pH to 6.0 GSH Treatment CTA1 Deletion PDE2 Deletion SNF1 deletion RIM15 deletion SIC1 Deletion SOD2 deletion High Glucose N-acetylcysteine Treatment Germline Ablation Reducing Protein Synthesis Impairing Chemosensory Perception Impairing mitochondrial electron transport Mianserin Treatment 272N18 Treatment Mirtazapine Treatment Cypoheptadine Treatment Methiothepin Treatment SER-1 Mutation L-proline supplementation snap-29 RNAi F35G12.4 RNAi cdtl-7 RNAi vha-2 RNAi mtch-1 RNAi cdc-25.3 RNAi gei-9 RNAi rpn-11 RNAi rol-3 RNAi rab-5 RNAi pkc-3 RNAi mex-5 RNAi his-69 RNAi his-55 RNAi grs-1 RNAi F54D5.11 RNAi F38E11.5 RNAi rpn-7 RNAi par-6 RNAi ndc-80 RNAi lys-1 RNAi let-92 RNAi his-2 RNAi gsk-3 RNAi pcf-11 RNAi snap-1 RNAi dcn-1 RNAi F16D3.4 RNAi rps-12 RNAi rpa-1 RNAi asb-1 RNAi eif-3.E RNAi rsp-8 RNAi T23D8.3 RNAi F09F7.3 RNAi rpb-8 RNAi chn-1 RNAi fkb-6 RNAi gpd-3 RNAi nhr-23 RNAi rsr-1 RNAi B0393.6 RNAi T04A8.11 RNAi F09F7.4 RNAi aph-2 RNAi aps-1 RNAi cdk-1 RNAi dpy-22 RNAi emb-27 RNAi evl-20 RNAi lin-5 RNAi mel-28 RNAi pat-2 RNAi rnr-2 RNAi rrt-1 RNAi C47D12.2 RNAi F02D10.6 RNAi dylt-1 RNAi F54D5.5 RNAi abce-1 RNAi trap-4 RNAi tag-341 RNAi R02D3.3 RNAi cnk-1 RNAi cyd-1 RNAi egl-15 RNAi eif-3.D RNAi gpr-2 RNAi hmg-4 RNAi hmp-2 RNAi krs-1 RNAi lsm-4 RNAi orc-2 RNAi ptr-24 RNAi rfc-1 RNAi rps-14 RNAi snr-5 RNAi vig-1 RNAi zyg-11 RNAi C14A4.11 RNAi C16C10.2 RNAi C47D12.8 RNAi gla-3 RNAi F26B1.2 RNAi F56C9.3 RNAi ceh-6 RNAi csn-5 RNAi cye-1 RNAi cyn-7 RNAi drs-1 RNAi eif-3.H RNAi emb-30 RNAi gut-2 RNAi his-42 RNAi hlh-1 RNAi irs-1 RNAi mex-6 RNAi ptp-3 RNAi ptr-4 RNAi rps-9 RNAi sbp-1 RNAi sos-1 RNAi sur-2 RNAi tba-5 RNAi vab-1 RNAi wah-1 RNAi glb-4 RNAi C14A4.14 RNAi rpb-3 RNAi F10C2.4 RNAi F43G9.5 RNAi F53H4.6 RNAi F54D5.9 RNAi M01F1.3 RNAi xrn-1 RNAi B0280.9 RNAi abi-1 RNAi synaptobrevin RNAi rpb-2 RNAi lam-2 RNAi C56C10.10 RNAi ZC395.10 RNAi dpy-27 RNAi pat-3 RNAi gei-4 RNAi ima-3 RNAi rab-1 RNAi rpn-2 RNAi rpt-1 RNAi T08A11.2 RNAi Y41E3.11 RNAi ins-17 RNAi paa-1 RNAi pie-1 RNAi srh-20 RNAi dcn-1 RNAi R144.2 RNAi ctdl-7 RNAi beta-transducin RNAi ATM mutation atp-3 RNAi nuo-2 RNAi cyc-1 RNAi cco-1 RNAi daf-2 RNAi ATP2 Mutation ATP2 Deletion Dietary restriction on low-fat diet Dietary restriction on high-fat diet High fat diet prx-5 RNAi pex1 mutation pex13 Mutation F18F11.1 RNAi prx-13 RNAi prx-11 RNAi daf-16 RNAi gsa-1 RNAi sptf-3 RNAi mpk-1 RNAi tbp-1 RNAi Y47D3A.29 RNAi bub-3 RNAi fzy-1 RNAi R03D7.4 RNAi max-2 RNAi ncbp-2 RNAi sptf-3 Overexpression age-1 RNAi age-1 mutation F13G3.7 RNAi lars-2 mutation clk-1 mutation clk-2 mutation F28B3.5 RNAi F57B10.3 RNAi HXK2 deletion D2030.4 RNAi phi-44 RNAi F26E4.6 RNAi W09C5.8 RNAi mrpl-47 RNAi cchl-1 RNAi K01C8.7 RNAi daf-2 mutation daf-16 mutation daf-11 mutation daf-7 mutation daf-17 mutation spe-26 mutation Germ-cell precursor ablation fem-3 mutation Sex rpt-5 RNAi pas-1 RNAi gdi-1 RNAi C15H9.9 RNAi rps-7 RNAi ttr-15 RNAi sqv-1 RNAi dnj-23 RNAi ZK632.4 RNAi F54E2.1 RNAi rpt-6 RNAi clec-266 RNAi dpy-23 RNAi ftn-2 RNAi F40A3.3 RNAi cri-3 RNAi cey-3 RNAi T08B2.7 RNAi tbh-1 RNAi ech-7 RNAi haf-4 RNAi vha-13 RNAi pyr-1 RNAi acs-4 RNAi F35G12.12 RNAi mlc-2 RNAi rps-16 RNAi rps-15 RNAi aco-2 RNAi atp-2 RNAi C34B2.6 RNAi his-37 RNAi F23B12.5 RNAi F01G4.6 RNAi inf-1 RNAi ucr-1 RNAi rpl-8 RNAi rps-5 RNAi pyc-1 RNAi mdh-1 RNAi eft-3 RNAi rps-0 RNAi eft-2 RNAi tbb-2 RNAi rpa-0 RNAi rpl-23 RNAi rps-20 RNAi rpl-31 RNAi rpl-1 gdh-1 RNAi cpn-3 RNAi B0250.5 RNAi rpl-10 RNAi rpl-7 RNAi cct-1 RNAi rpl-17 RNAi rps-11 RNAi rpl-3 RNAi rps-23 RNAi rack-1 RNAi pab-1 RNAi cct-8 RNAi sca-1 RNAi idhb-1 RNAi hel-1 RNAi rpt-2 RNAi his-1 RNAi his-5 RNAi iff-1 RNAi tag-61 RNAi acdh-10 RNAi hsp-6 RNAi his-10 RNAi sdha-2 RNAi ZK1320.9 RNAi H28O16.1 RNAi cgh-1 RNAi idha-1 RNAi his-31 RNAi act-4 RNAi sucg-1 RNAi rpl-19 RNAi his-46 RNAi his-56 RNAi nuo-4 RNAi cyn-1 RNAi nrs-1 RNAi rpl-4 RNAi pdhb-1 RNAi spg-7 RNAi Y37D8A.19 RNAi ers-1 RNAi pdha-1 RNAi acdh-12 RNAi acdh-3 RNAi sip1- RNAi hsp-60 RNAi ech-4 RNAi kat-1 RNAi suca-1 RNAi ZK669.4 RNAi trs-1 RNAi cpt-2 RNAi gcn-1 RNAi F27D4.1 RNAi ttr-2 RNAi B0303.3 RNAi tct-1 RNAi prdx-3 RNAi sucl-1 RNAi men-1 RNAi daf-21 RNAi col-8 RNAi his-38 RNAi his-67 RNAi his-64 RNAi his-14 RNAi his-26 RNAi atg-7 RNAi Dauer formation daf-4 mutation daf-3 mutation daf-1 mutation bra-1 mutation daf-8 mutation daf-14 mutation daf-5 mutation daf-7 RNAi VPS21 deletion Ghr knockout super-Trp53 ectopic Trp53 overexpression super-Ink4a/Arf super-Ink4a/Arf/p53 Pten overexpression Whole-body Sirt1 deletion in the adulthood Sirt1 overexpression hcf-1 mutation hcf-1 RNAi Rapamycin treatment ragc-1 RNAi skn-1 mutation Overexpression of constitutive nuclear SKN-1 daf-15 mutation daf-15 RNAi raga-1 RNAi glp-1 mutation rheb-1 RNAi eif-1 RNAi ifg-1 RNAi kri-1 mutation kri-1 RNAi rict-1 RNAi rsks-1 mutation rsks-1 RNAi Rapamycin treatment Inhibition of TOR signaling rrf-1 mutation sir-2.1 deletion sir-2.1 overexpression smk-1 RNAi smk-1 mutation bar-1 mutation ATG7 deletion VPS8 deletion VPS25 deletion VPS27 deletion Tert overexpression K5-Tert overxpression Tert re-activation Tert gene therapy SNCA overexpression eat-2 mutation Defects in the cilia of dendritic nerve endings sams-1 RNAi mak-2 RNAi B0035.12 RNAi E01A2.2 RNAi rps-27 RNAi F13G3.10 RNAi tag-322 RNAi old-2 overexpression old-1 overexpression old-1 RNAi vit-2 RNAi vit-5 RNAi SAM1 deletion OSH6 overexpression HES1 overexpression HES1 deletion INP53 deletion ATG18 deletion HNRNPD deletion Selection for starvation resistance Adcy5 knockout Prkar2b knockout CKA2 deletion CKB2 deletion VPS36 deletion CUP9 deletion APD1 deletion ZTA1 deletion SSN2 deletion ACB1 deletion TRM9 deletion RPL12B deletion ARO7 deletion FAR3 deletion FAR11 deletion PPG1 deletion BUL1 deletion PAN2 deletion ubh-4 RNAi rnf-5 RNAi C18E9.4 RNAi inx-14 RNAi F35D2.3 RNAi F40F8.5 RNAi drr-1 RNAi spt-4 RNAi cec-1 RNAi mecr-1 RNAi NAC treatment Vitamin C treatment shc-1 knockout Icariside II treatment Icariin treatment OSH7 overexpression Pink1 overexpression Curcumin treatment Curcumin treatment Quercetin treatment Gh antagonist overexpression 30% Dietary restriction Intermittent fasting Propargylglycine treatment Cbs overexpression Ilp2/Ilp3/Ilp5 mutation Ilp2 mutation CG11015 RNAi l(3)neo18 RNAi Dietary restriction by 1% yeast medium Malnutrition by 0.2% yeast medium CG5389 RNAi p53 dominant negative overexpression Thor mutation Thor overexpression foxo overexpression foxo mutation Indy mutation Sir2 overexpression Sir2 mutation Dominant negative Tor Dominant-negative S6k Constitutive active S6k overexpression Homozygous chico mutation Heterzygous chico mutation Orco mutation Heterozygous hypomorphic Rpd3 mutation Heterzygous Rpd3 null mutation Bmcp knockout elt-3 RNAi faah-1 overexpression mdt-15 mutation trx-1 mutation trx-1 overexpression slcf-1 RNAi slcf-1 mutation ckr-2 RNAi phb-2 RNAi phb-1 RNAi dve-1 RNAi cbp-1 overxpression cbp-1 RNAi ckr-1 RNAi cup-5 RNAi lgc-26 RNAi cup-4 RNAi cup-4 overexpression cup-4 mutation nlp-7 RNAi nlp-7 overexpression nlp-7 mutation aqp-1 mutation ins-7 RNAi unc-51 mutation Dgat1 knockout NAD supplementation Procyanidin treatment Apply polyphenol treatment (-)-epicatechin treatment ctbp-1 mutation Cisd2 overexpression Cisd2 knockout aPKC transposition Gadd45 overexpression esg transposition insc transposition sgg transposition LY294002 treatment Wortmannin treatment Rapamycin treatment PDTC treatment elt-6 RNAi Inactivation Wnt/b-catenin signaling ife-2 mutation BCY1 deletion bchs mutation bec-1 RNAi BLM mutation BRE5 deletion Increasing JNK signaling Bub1b mutation Replacement of Cebpa by Cebpb Overexpression of Cat and Sod1 Cat overexpression Sod overexpression CCR4 deletion Cct1 overexpression CDC25 mutation CDC6 mutation HPR1 deletion Transient CDC7 inactivation ced-3 mutation ced-3 RNAi ins-18 RNAi che-11 mutation che-13 mutation che-2 mutation che-2 mutation cher overexpression CIT2 deletion CIT2 overexpression ERCC8 mutation clk-1 overexpression clk-3 mutation COQ3 deletion COX1 deletion COX5 deletion CPR7 deletion CTF4 deletion ctl-1 mutation CYT1 deletion daf-10 mutation High sugar low protein diet Low calorie diet with low-sugar content Prop1 knockout GH overexpression Pou1f1 knockout Ghrhr knockout Igf1r knockout Heterozyogous fat-specific Insr knockout (FIRKO) Klotho disruption Klotho overexpression hsf-1 overexpression aakg-2 overexpression sod-1 overexpression lmp-2 overexpression sod1 overexpression ucp2 overexpression ucp-4 overexpression lyz overexpression lys-1 overexpression uba-1 overexpression Overexpression of ucp2 and aakg-2 daf-12 mutation daf-28 mutation daf-16 overexpression iftb-1 RNAi hsb-1 mutation daf-18 overexpression daf-18 mutation daf-19 mutation daf-6 mutation daf-9 mutation daz-1 mutation p53 mutation p53 overexpression p53 deletion mutation DNA2 deletion DNL4 deletion dod-17 RNAi dod-18 RNAi dod-19 RNAi dod-20 RNAi dod-21 RNAi dod-22 RNAi dod-23 RNAi dod-24 RNAi Down syndrom Pi3K92E mutation Neural-specific POSH overexpression mld heterozygous mutation eat-1 mutation eat-10 mutation eat-13 mutation eat-18 mutation eat-3 mutation eat-5 mutation eat-6 mutation eat-7 mutation EcR mutation Ef1alpha48D overexpression egl-4 mutation Mt2 overexpression mth mutation Hk mutation Sh mutation Cold temperature fer-15 mutation FOB1 deletion fog-1 mutation fog-2 mutation fog-3 mutation FPS1S overexpression Fwd overexpression GAL83 deletion gcy-18 RNAi gcy-6 RNAi Heterozygous Gh1 anti-sense transgene Homozygous Gh1 anti-sense transgene Homozygous GH1 deletion GLaz overexpression GLaz mutation GPA2 deletion GPD1 deletion GPR1 deletion Grisea mutation gro-1 mutation HAP4 overexpression HAP5 deletion HDA1 deletion YKU70 deletion YKU80 deletion hep overexpression hypomoprhic hep mutation HOG1 deletion SRS2 deletion HSC82 deletion hsf-1 RNAi hsf-1 mutation Simvastin treatment L744832 treatment GGTI-298 treatment hsp-16 overexpression hsp-16.48 RNAi hsp-6 overexpression HSPA9 overexpression HSP104 deletion HSP104 overexpression Hsp26 overexpression Hsp27 overexpression Hsp68 overexpression TERT overexpression Ubiquitinous SOD1 overexpression MAPT overexpression TXN overexpression LMNA mutation IDH2 deletion InRE19/InRp5545 transheterozygous mutation InrGC25/InrE19 transheterozygous mutation INS overexpression ins-1 RNAi ins-1 overexpression ins-21 RNAi ins-22 RNAi isp-1 mutation LAC1 deletion LAG1 deletion LAG2 overexpression LAG2 deletion lbp-7 RNAi let-363 mutation let-363 RNAi Activating let-60 mutation SIR2RP1 overexpression Mating type heterozygosity mec-1 mutation mec-8 mutation mes-1 mutation mev-1 mutation Overexpression of mitochondrial targeted CAT MORF4 overxpression MPT5 deletion MPT5 overexpression mrp-5 RNAi MSN2 MSN4 double mutation Msra knockout MSRA overexpression mtl-2 RNAi NCA3 deletion Eip71CD overexpression DNM1 deletion FIS1 deletion PaDnm1:ble nhr-49 RNAi nrh-49 mutation NMT1 mutation NNT1 overexpression NNT1 deletion Rapamycin treatment NAM treatment NPT1 deletion NPT1 overexpression Npy overexpression nuc-1 RNAi osm-1 mutation osm-3 mutation osm-5 mutation osm-6 mutation ovo mutation Heterozyogus Shc1 knockout Homozygous Shc1 knockout Hells mutation Pcmt overexpression pdk-1 mutation pept-2 RNAi pept-2 mutation pes-2 RNAi Petite pgl-1 mutation PHB1 deletion PHB2 deletion Akt1 mutation Plau overexpression PLD alpha antisense PNC1 overexpression PNC1 deletion pnk-1 RNAi POL1 deletion Homozygous knock-in of proof-reading deficient Polg Homozygous Prdx1 knockout PSEN1 mutation puc mutation PUF4 deletion BNA6 deletion rad-8 mutation RAD1 mutation RAD26 deletion RAD27 deletion RAD51 deletion RAD52 deletion RAD7 deletion RAD9 deletion RAS1 deletion RAS1 overxpression RAS2 overexpression Rdh overexpression REI deletion Rgn knockout RIF deletion ROM2 deletion RPD3 deletion SIR3 deletion RPL31A deletion RPL6A deletion RPL6B deletion RSR1 deletion RTG2 deletion RTG3 deletion SGS101 antisense RNAi SGS101 chemical induced overexpression scl-1 RNAi SCP1 deletion SCP1 overexpression sgk-1 RNAi SGS1 mutation SGS1 overexpression SIM1 deletion sip-1 RNAi SIP1 deletion SIP2 deletion ABP1 deletion SIR2 mutation SIR2 overexpression SIR3 activating mutation SIR4 deletion sir4-42 mutation Sirt1 knockout SLT2 deletion SNF1 overexpression SNF4 deletion Sod1 knockdown Sod knockout SOD1 overexpression SOD1 deletion Ascrobate treatment Sod2 overexpression Sod2 RNAi Sod2 overexpression SOD2 overexpression Sod2 homozygous knockout Sod2 heterozyogous knockout spe-10 mutation Eleutherococcus senticosus treatment Rhodiola rosea treatment DhHP-6 treatment DMSO treatment mev-5 mutation Jugelone treatment SSD1-V overexpression SSD1 deletion STE12 deletion HG246 mutation HG25 mutation HG96 mutation sug overexpression SUN4 deletion SWI4 deletion CKIepsilon mutation tax-2 mutation tax-4 mutation Terc deletion Overexpression of truncated TLC1 Top3b knockout TPK2 deletion TPS2 deletion Heterozyogus Trp53 truncation mutation Decreased Trp53 Trp63 knockout tub-1 mutation UCHL1 mutation unc-1 mutation unc-13 mutation unc-15 mutation unc-2 mutation unc-20 mutation unc-24 mutation unc-25 mutation unc-26 mutation unc-29 mutation unc-30 mutation unc-31 mutation unc-32 mutation unc-35 mutation unc-4 mutation unc-10 mutation unc-46 mutation unc-47 mutation unc-49 mutation unc-54 mutation unc-6 mutation unc-64 mutation unc-7 mutation unc-76 mutation unc-78 mutation unc-78 mutation unc-79 mutation unc-80 mutation URE2 deletion UTH1 deletion UTH3 deletion VhaSFD overexpression vit-1 RNAi WRKY6 deletion WRN mutation Ercc2 mutation YBR238C deletion MTC4 deletion SLM6 deletion IRC14 deletion ZDS1 deletion ZDS2 deletion D-glucosamine treatment NDT80 transient overexpression IME1 transient overexpression Elevation of histone expression Dnmt gene therapy Inhibition of mitochondrial respiration B0511.6 RNAi ztf-12 RNAi tbc-7 RNAi ttr-5 RNAi vps-37 RNAi cyc1 mutation D1054.8 RNAi ACH1 deletion CHL1 deletion Mir20a Overexpression scl-4 RNAi scl-8 RNAi wdr-23 RNAi maoc-1 RNAi lin-40 RNAi tkt-1 RNAi clec-1 RNAi set-9 RNAi cutl-28 RNAi aakb-1 RNAi dct-18 RNAi exos-3 RNAi Trxr-1 overexpression scrm-8 RNAi pup-2 RNAi cid-1 RNAi him-6 RNAi rab-10 RNAi tag-249 RNAi bus-8 RNAi vps-33.1 RNAi nol-5 RNAi dct-11 RNAi sbds-1 RNAi nol-1 RNAi dct-15 RNAi dct-13 RNAi NAM treatment pnc-1 RNAi pnc-1 overexpression dct-14 RNAi Y46G5A.6 RNAi aakb-2 RNAi dct-12 RNAi fbxa-220 RNAi acs-5 RNAi scl-20 RNAi sid-2 RNAi pbs-7 RNAi TMA29 deletion YBR225W deletion VMS1 deletion RRG1 deletion YDR124W deletion MTC5 deletion YDR132C deletion YDR248C deletion YDR262W deletion INM2 deletion YDR307W deletion YER186C deletion YER187W deletion YGL235W deletion YGR071C deletion ANS1 deletion YKL069W deletion SEG2 deletion VBA5 deletion YLR422W deletion TDA5 deletion DIF1 deletion GMC2 deletion YLR460C deletion YMR010W deletion YMR018W deletion YMR166C deletion YNR066C deletion TAE2 deletion YPR011V deletion UGA2 deletion UGA3 deletion crh-1 RNAi crtc-1 RNAi tax-6 RNAi ACO1 deletion TAD1 deletion FCY1 deletion IMD2 deletion SML1 deletion aak-1 mutation Phloridzin treatment Ganodermasides C treatment Acacb knockout Wings ablation/clipping Restriction of yeast Lep knockout Methionine restriction Akh knockdown Akh overexpression CG4389 knockdown CG7834 knockdown rpr overexpression Fat-body specific Akh knockdown Single-housing Pck1 overxpression Gonadermasides D treatment Ganodermasides A treatment Ganodermasides B treatment git3 deletion git3 constitutive activative mutation gpa2 constitutive active mutation sty1 deletion atf1 deletion atf1 overexpression wis1 constitutive active mutation pka1 deletion HST1 deletion PCK1 deletion PCK1 mutation ESA1 mutation GSH1 deletion ERG3 deletion SUR4 deletion LCB4 deletion HSP12 deletion NFU1 deletion FET3 deletion ATG16 deletion ATG2 deletion VPS30 deletion HXT17 deletion GUP1 deletion AIM4 deletion HHF1 deletion SFA1 deletion YHB1 deletion SFA1 YHB1 double mutation VPS20 deletion FRE6 deletion RCR2 deletion YDL180W deletion OPT2 deletion GTR1 deletion DAP2 deletion SLM4 deletion ATG10 deletion ATG11 deletion ERG2 overexpression FKH1 FKH2 deletion ADE4 deletion SWH1 deletion SRX1 deletion TCO89 deletion TSA1 activating mutation TSA1 deletion YPT7 deletion VAM7 deletion PKH2 deletion NYV1 deletion NDE1 NDE2 overexpression MDH1 overexpression LAT1 overexpression LAT1 deletion IPK1 deletion HST2 overexpression GUT2 overexpression GIS1 deletion ERG6 deletion ERG5 deletion CYR1 mutation CYR1 transposition BMH1 deletion ATG17 deletion ATG15 deletion AAT1 overexpression SCH9 Transposition hsp-12.6 mutation hif-1 RNAi hif-1 mutation ire-1 mutation egl-9 mutation ubc-18 overexpression ubc-18 mutation ubc-18 RNAi aqp-1 overexpression wwp-1 mutation wwp-1 RNAi wwp-1 overexpression smk-1 mutation Overexpression of constitutive nuclear DAF-16 skn-1 RNAi pha-4 mutation pha-4 RNAi pha-4 overexpression drr-2 RNAi clk-1 overexpression aak-2 constitutive active mutation Oligomycin treatment Blueberry extract supplementation Apple polyphenol supplementation Black tea extract supplementation Ilp3 mutation Ilp5 mutation Cbs RNAi ATG1 deletion tdp-1 mutation tdp-1 RNAi tdp-1 overexpression gar-3 RNAi gar-3 mutation unc-17 mutation cha-1 mutation F57A8.4 RNAi F57A8.4 mutation glc-4 RNAi glc-4 mutation shk-1 RNAi shk-1 mutation ins-35 RNAi ins-35 mutation let-4 RNAi TPS1 deletion NTH1 deletion NTH2 deletion TSL1 deletion TPS3 deletion ATH1 deletion Beauveriolide I treatment tps-1 RNAi tps-2 RNAi Trehalose treatment Trehalose treatment Hsp70 locus overexpression Igf1 overexpression nduf-2.2 RNAi wts-1 RNAi ant-1.1 RNAi abcx-1 RNAi Coq7 overexpression Coq7 knockout AGP1 deletion AKR1 deletion ARP1 deletion ATP1 deletion BAS1 deletion CAT5 deletion CCS1 deletion CLA4 deletion CLN3 overexpression CRC1 deletion CSR2 deletion CYT2 mutation FBP1 deletion FBP1 overexpression GCN2 deletion Spermidine treatment GCN5 deletion GIN4 deletion GLN3 deletion HAT2 deletion IDP3 deletion INM1 deletion INP51 deletion INP54 deletion IPT1 transposition IPT1 deletion ISC1 deletion CTA1 overexpression SIT4 deletion TEC1 deletion TEC1 mutation MAPK1 overexpression KSS1 deletion LIN1 deletion LYS9 deletion MEC1 deletion MEP2 deletion MEP3 deletion MRL4 deletion MXR1 deletion Methionine restriction MXR1 overexpression MXR2 deletion MXR2 overexpression NDI1 deletion NMD4 deletion PIB1 deletion RAD50 deletion RPL10 deletion RPL37B deletion RPL4A deletion RPL9A deletion RPL9B deletion RPO41 mutation RPS27B deletion RPS6A deletion RPS6B deletion SWF1 deletion TIF1 deletion TIF4631 deletion TMA19 deletion VAM3 deletion VHS1 deletion YDC1 overexpression YME1 deletion YPT6 deletion YSC84 deletion LEU3 deletion Sirt6 knockout Sirt6 overexpression BMH2 overexpression CTF8 deletion UGA4 deletion GAD1 deletion eat-2 RNAi enol-1 RNAi pyk-1 RNAi pyc-1 RNAi pck-1 RNAi pck-1 overexpression acdh-1 RNAi pod-2 RNAi fat-2 RNAi sbds-1 RNAi unc-52 RNAi hpd-1 RNAi icl-1 RNAi acdh-12 RNAi asp-3 RNAi cyc-2.1 RNAi clec-63 RNAi sodh-1 RNAi PEP4 overexpression Tyrosol treatment dcp-66 RNAi pas-3 RNAi arf-3 RNA cpf-2 RNAi wnk-1 RNAi nekl-2 RNAi phi-50 RNAi OSH7 mutation OSH6 mutation OSH3 deletion OSH3 overexpression aat-8 RNAi abu-11 overexpression acl-11 RNAi aco-2 RNAi ain-1 RNAi akt-1 RNAi alg-2 RNAi amt-2 RNAi arl-8 RNAi arx-4 RNAi abs-2 RNAi asg-1 RNAi asg-2 mutation atp-2 RNAi asm-3 RNAi Atg7 knockout Atg8a mutation Atg8a overexpression atp-4 RNAi atp-5 RNAi mboa-1 RNAi B0491.5 RNAi B0546.3 RNAi baf-1 RNAi agmo-1 RNAi blmp-1 RNAi C01F1.1 RNAi sco-1 RNAi cpna-3 RNAi C06A5.1 RNAi C07A9.2 RNAi C09B7.2 RNAi C11H1.3 RNAi C14A4.9 RNAi C18E9.10 RNAi mdt-26 RNAi C26B2.2 knockout C26B0.3 RNAi C27B7.7 RNAi vps-22 RNAi C29F9.1 RNAi C29F9.2 RNAi C32H11.1 RNAi C32H11.5 RNAi C33A12.1 RNAi C33H5.18 RNAi C35A11.3 RNAi C36H8.1 RNAi trim-9 RNAi C42C1.3 RNAi C46G7.2 RNAi C47E12.2 RNAi C48E7.2 RNAi C56G2.1 RNAi calu-1 RNAi car mutation cco-2 RNAi ccr-4 RNAi cct-4 RNAi cct-6 RNAi cdc-25.1 RNAi cdc-25.3 knockout cdk-7 RNAi Cdk5 mutation ceh-18 RNAi cel-1 RNAi cep-1 RNAi cep-1 mutation Hsp22 overexpression Hsp22 transposition bwa mutation cert mutation chk-1 RNAi cit-1.2 RNAi cm mutation cnb-1 mutation col-93 RNAi crn-5 RNAi cst-1 RNAi cst-1 overexpression cua-1 RNAi cul-1 RNAi cwp-4 RNAi cyp-33E2 RNAi cyp-42A1 RNAi C33H5.18 RNAi cku-70 RNAi Plasmodien infection Cynomorium songaricum supplementation Pinitol supplementation D-chiro-inositol supplementation Lazarillo supplementation SAG12 overexpression let-23 RNAi Black rice extract supplementation sir-2.4 RNAi SIR-2.4 overexpression Resveratrol supplementation Resveratrol supplementation Resveratrol supplementation Resveratrol supplementation Resveratrol supplementation YVH1 deletion YUH1 deletion YPK1 deletion YPC1 deletion YOS9 deletion YIA6 deletion YHC3 deletion YHF1 deletion WSC4 deletion TOS8 SKN1 deletion ZDS1 deletion VAC14 deletion OSH4 deletion OSH6 deletion Fgf21 overexpression YOL092W deletion N-acetyl-serotonin administration Melatonin supplementation fbxa-121 RNAi AFG3 deletion AVO2 deletion NF1 mutation NF1 overexpression dnc mutation Scgdelta deletion rut mutation DLP mutation Trx-2 mutation Sin3A overexpression g mutation TrxT overexpression CG30427 overexpression to overexpression PGRP-LF overexpression ImpL2 overexpression Hsp23 overexpression dj-1beta mutation CG10383 overexpression ry mutation SIFR overexpression sm overexpression CG10916 overexpression OSH2 deletion dor mutation hk mutation car mutation lt mutation rb mutation DJ-1alpha RNAi l(3)DTS3 mutation egm mutation fabp overexpression CG13890 overexpression PEP4 overexpression DDS treatment pyk-1 mutation pash-1 mutation mir-71 mutation lin-14 loss-of-function mutation lin-14 gain-of-function mutation jnk-1 overexpression Lamp2a expression restoration HAC1 deletion VMA1 overexpression VMA2 deletion AVT1 deletion AVT1 overexpression Moderate DR VPH2 overexpression concA treatment Ctf1 knockout Tsc1 overexpression gig overexpression Minocycline treatment SdhB mutation alg-1 RNAi Dcr-2 mutation lin-4 mutation lin-4 overexpression lin-14 RNAi mir-71 overexpression mir-238 mutation mir-246 mutation mir-246 overexpression mir-239 overexpression mir-239 mutation mir-14 mutation mir-58 mutation mir-61 mir-250(nDf59) mutation mir-64-66 mir-229(nDf63) mutation mir-80 mir-227(nDf53); mir-81-82(nDf54) Olive oil treatment C60-olive oil treatment C3 treatment Carboxyfullerene SOD mimetic treatment mir-124 mutation wrn-1 RNAi wrn-1 mutation Wrn mutation Metformin treatment Metformin treatment Metformin treatment Metformin treatment Diabenol treatment Sirt6 RNAi Bub1b overexpression LA treatment Pdf overexpression Bub1b mutation frh-1 RNAi Sir2 knockdown (R)-N-(2-heptyl)-N-methylpropargylamine treatment 2-ME treatment Arhgap1 knockout 2-MEA treatment Atm knockout Atr knockout Bax knockout Brca1 deletion Bub3 and Rae1 haploinsuficiency Casp-2 deficiency Cav1 knockout Cdkn1a knockout Efemp1 knockout ERCC1 and ERCC4 deficieny Fgf23 knockout Foxm1 deletion Foxm1 overexpression Fxn disruption Drd4 knockout tert knockout THC treatment THC treatment DATS treatment Gclc overexpression Gclm overexpression Jafrac1 overexpression mir-34 loss mir-34 upregulation GCN4 Deletion Nudt1 Overexpression Mnt Mutation mys Mutation Pka-C1 overexpression rho-7 knockout sdhC dominant negative overexpression Sir2 RNAi Sirt2 RNAi Sod mutation sun mutation Surf1 knockdown UCP2 overexpression 14-3-3epsilon mutation Akt1 RNAi alpha-Man-I mutation alpha-Man-I RNAi Atg2 overexpression Aut1 RNAi Bam mutation bsk RNAi CG17856 RNAi CG18809 RNAi CG9172 RNAi DNApol-gamma35 overexpression dys knockout dys RNAi E(z) mutation Edem1 mutation elav mutation esc mutation fh overexpression Gr63a mutation Gr63a overexpression GstS1 overexpression hebe overexpression Hsc70-3 overexpression Trichostatin A supplementation Hsp22 doxycyline-regulated overexpression Hsp22-promoter driven reporter overexpression Ablation of median neurosecretary cells Ilp2 RNAi CG3776 overexpression CG3776 underexpression kermit disruption kuk Overexpression LBR overexpression Lnk mutation Loco mutation magu overexpression Mlp84B RNAi MTF-1 overexpression Naam overexpression Nlaz mutation pex16 mutation Prx5 overexpression Prx5 mutation Pten overexpression Rbp9 mutation SNF4Agamma deletion snz mutation yata mutation Zw overexpression Hsp70Ba overexpression Spargel overexpression Constitutive miR-277 expression miR-277 inhibition mrps-5 RNAi nkcc-1 RNAi ttl-9 RNAi mrpl-1 RNAi mrpl-2 RNAi mrpl-37 RNAi nhr-62 Overexpression nhr-62 Mutation
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References:	11251834 Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. 20346071 Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans. 22225495 Metabotyping of long-lived mice using 1H NMR spectroscopy. 15096581 Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. 15574588 The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. 12750520 Mitochondrial dysfunction in the elderly: possible role in insulin resistance. 21386131 Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. 19301819 Quantitative lipid analysis and life span of the fat-3 mutant of Caenorhabditis elegans. 18423200 Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. 15383542 Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. 10224252 Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. 19801973 Induction of autophagy by spermidine promotes longevity. 19954334 Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice. 11707916 Longevity and aging: beneficial effects of exposure to mild stress. 10219000 Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. 22484922 Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. 17986602 Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. 18029465 Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. 10495400 DHEA deficiency syndrome: a new term for old age? 9215277 Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction. 20696905 Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. 21076178 Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. 12586694 SOD2 functions downstream of Sch9 to extend longevity in yeast. 19686215 A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans. 22496578 Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning. 22482728 Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. 9999999 Structural relaxation and defect annihilation in pure amorphous silicon. 17411345 Lifespan regulation by evolutionarily conserved genes essential for viability. 16741121 Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. 17608836 Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. 8136829 Genetic associations with human longevity at the APOE and ACE loci. 10818513 Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia. 8624216 Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. 8541369 Apolipoprotein E allele frequencies in an Italian population: relation to age and lipid profile. 9105559 Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. 12185856 Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity. 15621215 Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. 16971231 Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia. 3864931 Ataxia-telangiectasia: genetics, neuropathology, and immunology of a degenerative disease of childhood. Proceedings of a conference. Solvang, California, January 16-20, 1984. 16103914 New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. 12471266 Rates of behavior and aging specified by mitochondrial function during development. 15998808 A systematic RNAi screen for longevity genes in C. elegans. 12242224 A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. 18340043 Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. 22504417 Identification of common variants associated with human hippocampal and intracranial volumes. 22504421 Common variants at 12q14 and 12q24 are associated with hippocampal volume. 22509016 Midlife gene expressions identify modulators of aging through dietary interventions. 18059442 A modular network model of aging. 12447374 A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. 8638122 Determination of life-span in Caenorhabditis elegans by four clock genes. 11000115 Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. 19074434 Complex I function is defective in complex IV-deficient Caenorhabditis elegans. 8247153 A C. elegans mutant that lives twice as long as wild type. 1448167 Production of sperm reduces nematode lifespan. 22103665 Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. 17392428 Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. 17912023 Autophagy is required for dietary restriction-mediated life span extension in C. elegans. 20041217 TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. 21413222 Genetic and Environmental Regulation of Dauer Larva Development 17900898 The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. 20657825 Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. 21123740 Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. 9371826 A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). 12933651 Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. 12426394 "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. 11780111 p53 mutant mice that display early ageing-associated phenotypes. 15520276 Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. 22950424 Systems Biology and Bioinformatics in Aging Research: A Workshop Report. 22405073 Pten positively regulates brown adipose function, energy expenditure, and longevity. 22560220 SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. 18828672 Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. 19587680 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. 22560223 TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. 18358814 Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. 19079239 Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. 15253933 The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. 17266679 Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. 15296714 Role and regulation of starvation-induced autophagy in the Drosophila fat body. 22574120 C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline. 12826401 The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. 16860373 C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. 11242085 Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. 16530049 SMK-1, an essential regulator of DAF-16-mediated longevity. 17476212 PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. 15905404 Functional interaction between beta-catenin and FOXO in oxidative stress signaling. 11799246 Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. 12743030 Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1. 15200950 A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. 17612494 E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. 18043729 Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells. 19302372 Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. 20953148 Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. 22576335 MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping. 19013273 Telomerase reverse transcriptase delays aging in cancer-resistant mice. 15688016 Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. 21113150 Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. 22585399 Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. 13678781 Bone development and age-related bone loss in male C57BL/6J mice. 2921472 Studies in the distribution of body fat: I. Effects of age, sex, and obesity. 3322823 Insulin-like growth factors and aging. 16957737 p16INK4a induces an age-dependent decline in islet regenerative potential. 16957738 Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. 15734685 Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. 11919569 The aging of lympho-hematopoietic stem cells. 18283121 The longest telomeres: a general signature of adult stem cell compartments. 16582880 Increased p53 activity does not accelerate telomere-driven ageing. 21937764 Indy knockdown in mice mimics elements of dietary restriction. 16782295 Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein. 18331616 Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. 19239417 Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. 19229346 Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. 10617200 Regulation of lifespan by sensory perception in Caenorhabditis elegans. 19293945 A human protein interaction network shows conservation of aging processes between human and invertebrate species. 9768365 Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. 11591319 The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. 12845331 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. 19747233 The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. 21436897 Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. 18690010 A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery. 16293764 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. 22612594 The number of p16INK4a positive cells in human skin reflects biological age. 22559237 Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. 17662940 Type 5 adenylyl cyclase disruption increases longevity and protects against stress. 19536287 Disruption of protein kinase A in mice enhances healthy aging. 22377630 Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. 21151885 A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. 18832074 SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. 22216122 Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. 22653297 Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. 21855561 Curcumin-mediated lifespan extension in Caenorhabditis elegans. 22348084 Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. 19043800 Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43. 19370397 Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. 16682650 Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. 21930912 Increased transsulfuration mediates longevity and dietary restriction in Drosophila. 20195512 Molecular evolution and functional characterization of Drosophila insulin-like peptides. 19804760 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. 19968629 Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila. 19747824 Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. 16303568 Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. 15732191 Variation in the human TP53 gene affects old age survival and cancer mortality. 15175753 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. 18241326 Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. 19470468 Long-lived Indy and calorie restriction interact to extend life span. 11118146 Extended life-span conferred by cotransporter gene mutations in Drosophila. 12626742 Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. 17571923 No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. 15520384 Sir2 mediates longevity in the fly through a pathway related to calorie restriction. 15186745 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. 11292874 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. 11951037 Dietary restriction in long-lived dwarf flies. 17272684 Regulation of Drosophila life span by olfaction and food-derived odors. 12459580 Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. 16387864 Involvement of Drosophila uncoupling protein 5 in metabolism and aging. 18662544 An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. 21562563 N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. 22132200 The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. 17081160 Lifespan extension in Caenorhabditis elegans by complete removal of food. 17096674 Dietary deprivation extends lifespan in Caenorhabditis elegans. 16387300 Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. 21334311 The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. 21040400 Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. 19783783 Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. 19812672 Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. 19924292 Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. 19883616 Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. 18219227 Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. 22291164 Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 20717869 Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans. 19164523 The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. 18043747 DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth. 22661501 A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. 19451219 Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. 22661237 The second international conference "genetics of aging and longevity". 8195187 Cloning and characterization of LAG1, a longevity-assurance gene in yeast. 12598614 blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. 12958363 Autophagy genes are essential for dauer development and life-span extension in C. elegans. 18282106 A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. 5770175 Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients. 21447998 A genomic analysis of chronological longevity factors in budding yeast. 14602080 JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. 15208629 BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. 15289464 Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. 10982846 C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. 8108730 Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. 9858546 FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. 11805047 Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. 12620118 A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. 9428525 Extrachromosomal rDNA circles--a cause of aging in yeast. 8552037 The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination. 11756539 hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. 2698814 Replication control and cellular life span. 1990268 A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. 12136014 Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. 10873623 Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. 14559957 Unique lipoprotein phenotype and genotype associated with exceptional longevity. 1732156 Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. 2428682 Mutant sensory cilia in the nematode Caenorhabditis elegans. 10508861 Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. 7705621 Mutations affecting the chemosensory neurons of Caenorhabditis elegans. 1986232 Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. 14156156 COCKAYNE'S SYNDROME. A REPORT OF FIVE NEW CASES WITH BIOCHEMICAL, CHROMOSOMAL, DERMATOLOGIC, GENETIC AND NEUROPATHOLOGIC OBSERVATIONS. 514720 The Cockayne syndrome: an evaluation of hypertension and studies of renal pathology. 9020081 Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. 11136229 A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. 9789046 The genetics of caloric restriction in Caenorhabditis elegans. 7768437 Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. 11959146 CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA. 10202142 CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. 10330149 Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. 2999848 A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures. 10759557 A causal link between respiration and senescence in Podospora anserina. 11361336 Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells. 12024027 Mutations in DNA replication genes reduce yeast life span. 10335847 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. 12610632 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. 12124627 Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. 16311627 Increased life span due to calorie restriction in respiratory-deficient yeast. 22672579 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. 8900272 Dwarf mice and the ageing process. 8100276 Premature ageing in transgenic mice expressing different growth hormone genes. 14583653 Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. 11718806 The Snell dwarf mutation Pit1(dw) can increase life span in mice. 11371619 Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. 10875265 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. 12483226 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. 12543978 Extended longevity in mice lacking the insulin receptor in adipose tissue. 9363890 Mutation of the mouse klotho gene leads to a syndrome resembling ageing. 16123266 Suppression of aging in mice by the hormone Klotho. 11744049 Dietary restriction alters cell proliferation in rats: an immunohistochemical study by labeling proliferating cell nuclear antigen. 22661299 Chronic caloric restriction partially protects against age-related alteration in serum metabolome. 7789761 Genes that regulate both development and longevity in Caenorhabditis elegans. 10360574 Signals from the reproductive system regulate the lifespan of C. elegans. 8807293 Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. 7219552 Interacting genes in nematode dauer larva formation. 19460140 A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study. 11747825 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. 16720740 daf-16 protects the nematode Caenorhabditis elegans during food deprivation. 22265419 HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. 16153634 Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. 8601482 The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. 9475731 Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. 10428762 The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. 9504918 An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. 8005442 A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. 11782415 DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. 11740945 A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. 3350212 Mutants of Caenorhabditis elegans that form dauer-like larvae. 12935877 In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. 10521401 The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. 3158266 Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. 11868902 Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies. 12610309 Steroid control of longevity in Drosophila melanogaster. 8462849 The genetics of feeding in Caenorhabditis elegans. 2508089 Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. 12571101 Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. 15533947 DNA methyltransferase gene dDnmt2 and longevity of Drosophila. 9794765 Extended life-span and stress resistance in the Drosophila mutant methuselah. 8582611 Regulation of gene expression is linked to life span in adult Drosophila. 9799084 The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. 11065130 A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains. 11778046 Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. 10230397 Elimination of replication block protein Fob1 extends the life span of yeast mother cells. 2341035 fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans. 10747056 Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. 11076749 FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. 7713418 The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans. 12000449 Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. 10921902 Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. 12057928 Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. 12915652 Reduced longevity in untreated patients with isolated growth hormone deficiency. 16581512 Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. 16581513 Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. 12391171 High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. 8804410 GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence. 9271578 Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. 12213553 Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. 10512855 Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. 8962081 HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. 8754818 Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. 9635192 Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. 9501103 Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. 11861900 SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. 11290710 The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. 14668486 Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. 22737247 Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. 12882326 Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. 11959102 Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. 17908928 Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. 8643570 Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. 9851879 Heat stress-induced life span extension in yeast. 15308776 Multiple-stress analysis for isolation of Drosophila longevity genes. 9454332 Extension of life-span by introduction of telomerase into normal human cells. 10719757 Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. 8610185 Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. 1763030 Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. 11408621 Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. 12230882 Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. 19030232 Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. 11292875 A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. 11274053 Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. 11709184 Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. 10631108 Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. 11016890 Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. 10198056 Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. 9872981 Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. 8760941 LAG2, a gene that determines yeast longevity. 14668850 Genetics: influence of TOR kinase on lifespan in C. elegans. 16164423 LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans. 12383511 Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death. 11526246 A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. 10326548 Siblings of centenarians live longer. 8454201 a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects. 8625846 The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts. 1783292 Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. 9716135 A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. 2233820 A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. 15879174 Extension of murine life span by overexpression of catalase targeted to mitochondria. 9891081 Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. 6879195 Evidence for the recessive nature of cellular immortality. 3413074 Genetic analysis of indefinite division in human cells: identification of four complementation groups. 10838077 Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. 8454632 Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. 17172436 Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. 7845352 A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrest. 9584615 Molecular mechanisms of yeast aging. 7859289 Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. 9150138 Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. 9504907 Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. 14741356 Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. 18225956 Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. 11867705 High-quality life extension by the enzyme peptide methionine sulfoxide reductase. 16611701 Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. 15911777 No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. 8810036 Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. 7586026 NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae. 22310715 Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila. 17173038 Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. 15719061 Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. 2406721 Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein 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of Mn superoxide dismutase does not increase life span in mice. 21700873 Gametogenesis eliminates age-induced cellular damage and resets life span in yeast. 20832724 Elevated histone expression promotes life span extension. 11292860 Regulation of longevity and stress resistance by Sch9 in yeast. 22790951 New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound. 22279548 Genetic signatures of exceptional longevity in humans. 19837933 Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. 19915151 Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. 17190939 A genotype of exceptional longevity is associated with preservation of cognitive function. 18059160 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult 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22622083 Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. 23066506 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. 21325893 Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. 21857805 Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. 11462771 Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. 18212404 Does melatonin play a role in aging processes? 21641548 Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. 17369827 Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. 17855453 Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. 17933869 Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. 17567437 Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. 17435236 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. 17301052 Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila. 22768842 Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. 20519778 Comparative transcriptional profiling identifies takeout as a gene that regulates life span. 18434551 Drosophila germ-line modulation of insulin signaling and lifespan. 20036725 Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22. 14734639 Overexpression of the small 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22216232 A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae. 16418483 Extension of chronological life span in yeast by decreased TOR pathway signaling. 19805817 Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response. 19424415 Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. 18469137 Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. 15722108 Genes determining yeast replicative life span in a long-lived genetic background. 21918615 Identification of longevity genes with systems biology approaches. 20421943 A microarray-based genetic screen for yeast chronological aging factors. 19458476 Autophagy is required for extension of yeast chronological life span by rapamycin. 21901113 Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. 22615903 Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan. 17544056 Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span. 11024000 An intervention resembling caloric restriction prolongs life span and retards aging in yeast. 22303396 Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan. 20622262 Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. 17710147 DNA replication stress is a determinant of chronological lifespan in budding yeast. 12855292 The Ras and Sch9 pathways regulate stress resistance and longevity. 18381895 The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie 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the disposable soma theory? 22884974 Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology. 20228939 Effect of feeding regimens on circadian rhythms: implications for aging and longevity. 21376793 Long-lived mice exhibit 24 h locomotor circadian rhythms at young and old age. 20580916 Chronobiological aspects of nutrition, metabolic syndrome and obesity. 21402069 Calorie restriction and prevention of age-associated chronic disease. 21981968 Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. 20395504 Extending healthy life span--from yeast to humans. 22608008 Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. 22593546 Timed high-fat diet resets circadian metabolism and prevents obesity. 23050095 Meal frequency patterns determine the phase of mouse peripheral circadian clocks. 22217096 Effects of aging on the molecular circadian oscillations in Drosophila. 22395806 The circadian clock and pathology of the ageing brain. 21454295 Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. 12149444 Effects of aging on central and peripheral mammalian clocks. 22268765 Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. 22705307 Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components. 22672634 Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways. 19854863 Metabolism and circadian rhythms--implications for obesity. 23691220 Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae. 23698443 Mitonuclear protein imbalance as a conserved 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microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements. 18379589 MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. 22479342 MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. 22128178 MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. 21574070 Voting with their mice: personal genome testing and the "participatory turn" in disease research. 22090473 Genome-environment interactions that modulate aging: powerful targets for drug discovery. 22327899 A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. 23098078 The role of DNA methylation in aging, rejuvenation, and age-related disease. 22533440 Accelerated aging versus rejuvenation of the immune system in heterochronic 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expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. 16799135 A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. 11780357 Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang. 15547317 Single nucleotide polymorphisms: aging and diseases. 8018664 Aging and genetic variation of plasma apolipoproteins. 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The Strong Heart Study. 8018666 Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. 1867194 The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. 3698268 Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. 11882522 Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. 16799145 Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. 16803999 Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. 9887369 Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). 15105583 Assessing genetic association with human survival at multi-allelic loci. 15820493 Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screening genetic polymorphisms related to specific phenotypes. 10496068 Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins. 9761238 Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians. 11773214 Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study. 11602206 Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity. 12556235 The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. 9622284 In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians. 9050915 DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus. 12646697 Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. 15939070 Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study. 11162685 Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. 11857056 Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. 9389323 Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. 12566526 Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population. 14501185 The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women. 16804002 Heat-shock protein 70 genes and human longevity: a view from Denmark. 12742533 Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population. 11772518 Allele frequencies of +874T--&gt;A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. 12843179 Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. 11857058 Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. 15582274 Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. 16474933 Association between the MLH1 gene and longevity. 16142417 The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity. 12889841 Effect of six candidate genes on early aging in a French population. 15236769 Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. 16095668 Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians. 15569360 The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. 16269080 Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population. 20569235 HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. 23695394 A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age. 23236401 MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ. 18789835 MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. 22628407 miR-23a promotes the transition from indolent to invasive colorectal cancer. 18719391 Mechanisms of microRNA deregulation in human cancer. 2035418 Advances in the concepts of intensive care. 22996741 MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression. 22027551 Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane. 20354188 MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. 22027557 Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. 22700217 Dynamics of olfactory and hippocampal neurogenesis in adult sheep. 12882410 Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. 23125046 TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis. 11772517 The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. 15466015 Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. 19367319 Human longevity and 11p15.5: a study in 1321 centenarians. 21299522 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. 11053677 Common gene variants, mortality and extreme longevity in humans. 9425225 HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. 12044933 Fixation of deleterious alleles, evolution and human aging. 12954489 Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe. 16804001 Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians. 22960875 Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians. 15177664 Polymorphic metabolic susceptibility genes and longevity: a study in octogonarians. 3632129 Polymorphism of heterochromatin areas on chromosomes 1, 9, 16 and Y in long-lived subjects and persons of different ages in two regions of the Soviet Union. 22303384 Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. 17493663 Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. 10744171 The contribution of factor VII gene polymorphisms to longevity in Scottish nonagenarians. 20426625 HLA and KIR frequencies in Sicilian Centenarians. 15050300 Immunological markers contributing to successful aging in Bulgarians. 22336474 Cholesteryl ester transfer protein TaqIB polymorphism and its association with serum lipid levels and longevity in Chinese Bama Zhuang population. 20720309 An age-related decrease in factor V Leiden frequency among Polish subjects. 18756013 Power for genetic association study of human longevity using the case-control design. 21798861 Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population. 18545700 Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. 16257164 Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. 17445222 14th International HLA and Immunogenetics Workshop: report on the immunogenetics of aging. 19249341 Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. 12547486 Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins. 22113349 Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. 15621216 Biological evidence for inheritance of exceptional longevity. 23273182 Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China. 16518718 Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity. 22456784 The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population. 19763607 Gene variants as determinants of longevity: focus on the inflammatory factors. 20834067 Joint influence of small-effect genetic variants on human longevity. 17393087 Correlation between haplotype of apolipoprotein B gene and natural longevity persons in Uygur nationality. 18341427 Genetic polymorphisms and human aging: association studies deliver. 23376243 Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. 21388494 Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans. 10219002 C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians. 14530863 Association analysis of the SHC1 gene locus with longevity in the Japanese population. 15664628 Interleukin-6 -174G/C polymorphism and longevity: a follow-up study. 22773346 Linkage and association of successful aging to the 6q25 region in large Amish kindreds. 17934638 Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study. 23372024 The Epidemiology of Longevity and Exceptional Survival. 17506774 Interleukin 6 variable number of tandem repeats (VNTR) gene polymorphism in centenarians. 16405962 Impact of genetic variations in the WRN gene on age related pathologies and mortality. 21051524 Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals. 20388090 Anti-inflammatory heat shock protein 70 genes are positively associated with human survival. 19421891 The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect. 11788960 Mortality differences by APOE genotype estimated from demographic synthesis. 11485022 The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians. 21703254 APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism. 21418511 Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. 22722495 Osh6 links yeast vacuolar functions to lifespan extension and TOR. 23773067 Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here. 23704949 Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction. 23683827 Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation. 20505758 microRNA expression patterns reveal differential expression of target genes with age. 23644076 Microglia during development and aging. 15676284 A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. 11943467 An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. 11672987 Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region. 11448941 Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. 14580859 Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. 12297342 The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach. 22465014 Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster. 11015124 Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene". 10463944 Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. 15036421 Variation in the SHC1 gene and longevity in humans. 10996007 Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. 18448515 Evidence that the gene encoding insulin degrading enzyme influences human lifespan. 22729909 Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China. 21424155 Role of prothrombotic polymorphisms in successful or unsuccessful aging. 20884733 Effects of FOXO genotypes on longevity: a biodemographic analysis. 16960022 Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. 21113673 PTPN22 1858C&gt;T (R620W) functional polymorphism and human longevity. 20230275 Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity. 10583447 Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age. 15028112 A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (&lt;35 repeats) are rare in centenarians. 23354683 Association of the K153R polymorphism in the myostatin gene and extreme longevity. 15888337 Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. 18511746 Adiponectin levels and genotype: a potential regulator of life span in humans. 16955215 Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. 21726414 Immunogenetics of ageing. 11795532 BRCA1 gene sequence variation in centenarians. 19502260 Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population. 10705035 Genetics of aging: lessons from centenarians. 15050299 Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. 22234866 Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. 23128285 Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. 17048073 Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity. 15130674 Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish. 23186209 Mitochondriogenesis genes and extreme longevity. 10577935 P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. 11938442 A centenarian-only approach for assessing gene-gene interaction in human longevity. 21972126 Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity. 18458168 Mitochondrial haplogroups: ischemic cardiovascular disease, other diseases, mortality, and longevity in the general population. 12965974 Understanding the determinants of exceptional longevity. 16251894 Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. 19245677 Gene expression profiles associated with aging and mortality in humans. 20003469 Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population. 22340368 Human longevity and common variations in the LMNA gene: a meta-analysis. 18256523 The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. 21222045 The relationship between fertility and lifespan in humans. 17389728 Genetic variation and human aging: progress and prospects. 10069711 Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. 20819792 Association of CYP19 and ESR1 pleiotropic genes with human longevity. 19377912 Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism. 17234815 Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of Hellenic origin. 11772516 Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. 20855428 Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cells. 21332925 Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. 12483296 Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. 22743239 UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts. 17903295 Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. 11269751 Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes. 22985157 Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. 11213279 Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. 21340542 A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity. 15288696 Investigation of KIR diversity in immunosenescence and longevity within the Irish population. 20174870 Gender-specific association of ADA genetic polymorphism with human longevity. 21612516 Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins. 20434535 Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects. 18511747 A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism. 16424284 Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging. 22174011 Genomics of human health and aging. 12676903 Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. 22496539 Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. 16893392 The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study. 9147371 HLA and longevity or aging among Shanghai Chinese. 16518704 Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy. 19887537 The IRS2 Gly1057Asp variant is associated with human longevity. 14528043 Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age. 21827845 Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity. 17261792 Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily. 22406557 Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. 16487435 Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians. 19489743 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. 18759861 Mitochondrial DNA haplogroups in a Chinese Uygur population and their potential association with longevity. 20824210 High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. 22569962 Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. 17714903 Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians. 12714263 Association between the HFE mutations and longevity: a study in Sardinian population. 9106548 Methylenetetrahydrofolate reductase thermolabile variant and human longevity. 21262335 Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population. 16015282 No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians. 11470126 Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST). 12082503 Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. 9654200 Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci. 17452725 Liver X receptor alpha associates with human life span. 20816691 A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. 20199671 A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population. 20582731 Variations in short tandem repeats deduced on the basis of the number of repeats and the relationship of these variations with longevity. 9587069 Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. 16799134 Paraoxonase activity and genotype predispose to successful aging. 17339647 Absence of relationship between MTTP haplotypes and longevity. 21407269 Association of TH01 with human longevity revisited. 21945877 Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China. 12714268 HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. 23133589 Bitter taste receptor polymorphisms and human aging. 16574194 A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival. 9792194 Apolipoprotein E and longevity among Han Chinese population. 18761080 Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population. 19793722 Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. 21614448 Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans. 20599431 The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with 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A study on a Spanish cohort. 18931934 Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations. 11640949 Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. 19707883 Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. 22156437 Discovery of functional gene variants associated with human longevity: opportunities and challenges. 12581796 Association between the HLA-DR alleles and longevity: a study in Sardinian population. 15621218 Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. 21147083 Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population. 19840767 Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity. 23339001 Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenarians. 6240576 Genetic study of high longevity index populations. 7089955 HLA and longevity. 9533408 Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease. 9585593 A model for antagonistic pleiotropic gene action for mortality and advanced age. 9754988 Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY. Role of CYP2D6 and CYP2C19 in longevity. 9759473 Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. 9854023 Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. 10643896 Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. 11053670 Does a retrograde response in human aging and longevity exist? 11280044 A study of French centenarians: are ACE and APOE associated with longevity? 11292511 Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data. 11404057 Mitochondrial DNA polymorphism: its role in longevity of the Irish population. 11592926 Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus. 11965496 Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians. 12076681 The genetics of aging. 12384792 Mitochondrial DNA 5178A polymorphism and longevity. 15130757 Modest implication of interleukin-6 promoter polymorphisms in longevity. 15195682 Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. 15236771 Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles. 15241482 Paraoxonase 1 polymorphisms and survival. 15472150 The catalase -262C/T promoter polymorphism and aging phenotypes. 15621217 Exploring the genetics of longevity in the Old Order Amish. 15677572 Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. 15720298 Haplotype effects on human survival: logistic regression models applied to unphased genotype data. 16803995 The genetics of human longevity. 16848980 Genome-wide approaches to understanding human ageing. 17077204 Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians. 17090420 Genes, ageing and longevity in humans: problems, advantages and perspectives. 17331249 SOD2 polymorphisms: unmasking the effect of polymorphism on splicing. 17364902 Molecular genetic studies on relationships among longevity, diseases, and HLA-DRB1/DQB1 allelic polymorphism. 17574707 Role of VEGF gene variability in longevity: a lesson from the Italian population. 17784782 Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. 17869046 Hemostasis factors and aging. 17989723 A novel sampling design to explore gene-longevity associations: the ECHA study. 18379014 Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity. 18510744 Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. 18765803 FOXO3A genotype is strongly associated with human longevity. 19000922 Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. 19196970 Association of FOXO3A variation with human longevity confirmed in German centenarians. 19428448 The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. 19459036 TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. 19641616 Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. 20003397 The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population. 20011587 RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. 20201642 Associations of polymorphisms in adiponectin and leptin genes with men's longevity. 20362697 No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis. 20407924 Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes. 20549353 Inflammation, genetic background and longevity. 20595579 Genetic signatures of exceptional longevity in humans. 20633545 SIRT1 variants are associated with aging in a healthy Han Chinese population. 20800603 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. 20849522 Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. 21115528 Genomics of human longevity. 21407828 Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism. 21503725 Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach. 21865054 Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy. 22136229 Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. 22265023 Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals. 22524405 The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations. 22912757 Evaluation of the role of SNCA variants in survival without neurological disease. 22985084 Gender-specific association between FSHR and PPARG common variants and human longevity. 23020224 Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 23162014 Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults. 19641380 Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. 22533364 Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality. 14615589 Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. 11282420 Biological and clinical implications of the MTHFR C677T polymorphism. 19027825 Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. 23040522 Apolipoprotein E and familial longevity. 16896546 Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). 12855277 Genetics of exceptional longevity. 16608414 Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians. 18834923 Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population. 21115529 Genetics and genomics of human ageing. 16970956 Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians. 21782286 A genome-wide association study of aging. 18034366 Lack of replication of genetic associations with human longevity. 22607627 How genes influence life span: the biodemography of human survival. 17888441 Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study. 12375058 Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease. 18316725 Functionally significant insulin-like growth factor I receptor mutations in centenarians. 23460298 Sexual experience restores age-related decline in adult neurogenesis and hippocampal function. 12859354 Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. 18335035 SirT1 regulates energy metabolism and response to caloric restriction in mice. 22239951 Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches. 2845344 Extensive defects of mitochondrial electron-transfer chain in muscular cytochrome c oxidase deficiency. 9449878 Mitochondrial genotype associated with longevity. 11792841 Association of human aging with a functional variant of klotho. 7460386 Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature. 8265666 The gene responsible for Werner syndrome may be a cell division "counting" gene. 11316787 Loss of Werner syndrome protein function promotes aberrant mitotic recombination. 23936746 Aging, neurogenesis, and caloric restriction in different model organisms. 23891729 Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis. 16356642 Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors. 21471153 The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. 23083790 Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects. 1000 The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. 42663 [Symposium on major histocompatibility antigens (HLA) and diseases. Supplement: genetic factor in Takayasu disease (author's transl)]. 437 Kinetics of cyanate and imidazole binding to hemin in micelles. 56000 [Bacterial flora in patients with prostatic adenoma]. 3000 Preparation and storage of platelet concentrates. 20020919 A hierarchical clustering methodology for the estimation of toxicity. 999984 [DNA degradation during standard alkaline of thermal denaturation]. 1752787 Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension. 1752803 Effect of supplemental lysocellin and tetronasin on growth, ruminal and blood metabolites, and ruminal proteolytic activity in steers grazing ryegrass. 1752811 Divergent selection for postweaning feed conversion in Angus beef cattle: II. Genetic and phenotypic correlations and realized heritability estimate. 1752808 Simulation of life-cycle efficiency of lamb and wool production for genetic levels of component traits and alternative management options. 1352306 Measurement of amino acid compositions of glycoprotein systems by gas-phase hydrolysis and reversed-phase high-performance liquid chromatography. 1752810 Divergent selection for postweaning feed conversion in Angus beef cattle: I. Mean comparisons. 1352890 Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa. 1754223 Nerve-muscle pedicle reinnervation of the paralyzed vocal cord. 1754230 [Non-epithelial malignant neoplasms of the larynx]. 1754243 [Use of ultrasonography in the diagnosis of laryngeal cancer]. 1754226 The spectrum of vocal dysfunction. 1352315 Quantitative image cytometry of hepatocytes expressing gamma-glutamyl transpeptidase and glutathione S-transferase in diethylnitrosamine-initiated rats treated with phenobarbital and/or phthalate esters. 1752829 Exogenous opioids increase plasma prolactin in Holstein calves primarily via a dopaminergic mechanism. 1754272 Counseling to avoid AIDS. 1754300 Developmental regulation of expression of C-reactive protein and serum amyloid A in Syrian hamsters. 1752838 Reactivity in self-recording: obtrusiveness of recording procedure and peer comments. 1752858 Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. 1754299 Prenatal diagnosis and neonatal monitoring of a fetus with glutaric aciduria type II due to electron transfer flavoprotein (beta-subunit) deficiency. 1754289 Adenosine in the pediatric population: nursing implications. 1754297 Oral L-alloisoleucine loading studies in healthy subjects and in patients with maple syrup urine disease. 1754304 Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier. 1352324 Diabetes incidence in users and non-users of antihypertensive drugs in relation to serum insulin, glucose tolerance and degree of adiposity: a 12-year prospective population study of women in Gothenburg, Sweden. 1754325 [Structure of interstitial nephritis in children]. 1752879 Microbial contamination in allografted wound beds in patients with burns. 1352326 Pseudoathetosis as a presenting symptom of spinal multiple sclerosis. 1352327 Brachial plexus neuropathy associated with scrub typhus: report of a case. 23938363 Omics technologies and the study of human ageing. 23746838 The hallmarks of aging. 23594911 Computational solutions for omics data. 23883936 Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease. 1754336 [Results of the treatment of glomerulonephritis in children with hepatitis B]. 1752875 Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award. 1754338 [Crigler-Najjar syndrome in an infant during the 1st year of life]. 20404021 Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. 1752905 Epilepsy and cardiac surgery. 1754356 [Clinical syndromes and treatment tactics in cow's milk intolerance in young children]. 1352337 Localization of obscure gastrointestinal bleeding by technetium 99m-labeled red blood cell scintigraphy. 1352336 Detection of mass lesions in the collapsed lung by ultrasonography. 1754384 Molecular cloning of the gene encoding the bovine brain ribonuclease and its expression in different regions of the brain. 1754396 Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells. 1752961 Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. 1754417 Dinucleotide repeat polymorphism at D16S287. 1752966 Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney. 1752969 Evaluation of masticatory function following orthognathic surgical correction of mandibular prognathism. 1752968 Restricted opening of the mouth with an extra-articular cause in children. 1352961 Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis. 1752922 Clinical use of growth hormone-releasing factor for induction of superovulation. 1752910 Professional oaths--pharmacy can lead the way. 1752914 Comparative pharmacokinetics of temazepam Gelthix and liquid-filled soft gelatin capsules. 1352373 Medicolegal aspects of benzodiazepine dependence. Duties and responsibilities of doctors. 1752976 Guidelines on testing for the lupus anticoagulant. Lupus Anticoagulant Working Party on behalf of the BCSH Haemostasis and Thrombosis Task Force. 1752975 Current concerns in haematology. 3: Blood count calibration. 1752984 Prospective study of quantitative aspects of audit in a large general histopathology laboratory. 1352384 Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil. 1352980 B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity. 1753022 Meeting the challenge of cancer care and prevention in Europe. 1754503 Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT Survey. 23782614 Crowdsourcing for bioinformatics. 23931992 The need for research maps to navigate published work and inform experiment planning. 22162133 Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. 16904174 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 23972281 EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update. 22973865 A new ontology (structured hierarchy) of human developmental anatomy for the first 7 weeks (Carnegie stages 1-20). 21204651 Bioinformatics in aging research: a workshop report. 23998809 LongevityMap: a database of human genetic variants associated with longevity. 22067257 Epigenetic-aging-signature to determine age in different tissues. 19428454 A case study of "disorganized development" and its possible relevance to genetic determinants of aging. 11283189 Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population. 23994476 Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression. 24138928 DNA methylation age of human tissues and cell types. 24188080 In-Silico-Approaches and the Role of Ontologies in Aging Research. 23219718 State of the art and open challenges in community-driven knowledge curation. 15355246 Evolutionary and mechanistic theories of aging. 11972154 Mechanisms of ageing: public or private? 17460161 Biological aging is no longer an unsolved problem. 19826117 Qualitative age interactions in breast cancer studies: mind the gap. 18838890 Qualitative age-interactions in breast cancer: a tale of two diseases? 19071000 How age affects the biology of breast cancer. 24293183 Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: A novel teleost fish model of negligible senescence. 15542015 Enhancing HMM-based biomedical named entity recognition by studying special phenomena. 23159498 Biomedical text mining and its applications in cancer research. 23948932 Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation? 25038186 Association between <i>FOXO3A</i> gene polymorphisms and human longevity: a meta-analysis. 24930376 PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. 24924924 Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population. 24792352 Mitochondrial DNA polymorphisms associated with longevity in the Turkish population. 24688116 Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. 24549597 Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus. 24534555 ApoE gene and exceptional longevity: Insights from three independent cohorts. 24468472 Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy. 24465950 Investigation of complement component C4 copy number variation in human longevity. 24284407 Possible role of -374T/A polymorphism of RAGE gene in longevity. 24244950 Meta‐analysis of genetic variants associated with human exceptional longevity. 24164579 Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis. 24163049 The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. 24126160 Rare and common variants in the Apolipoprotein E gene in healthy oldest old. 23839864 Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)". 23770741 Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. 23755540 [Association between 242C &gt; T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population]. 23623925 The ACE DD genotype and D-allele are associated with exceptional longevity: a meta-analysis. 23607278 A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family. 23572278 Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. 23562826 The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy. 23505545 SIRT1 polymorphism, long-term survival and glucose tolerance in the general population. 23450480 [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]. 23406923 The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians. 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